| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Medicine/Gastroenterology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States; VA Medical Center, New Orleans, Louisiana, United States
2 Medicine/Gastroenterology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States; VA Medical Center, United States
3 Medicine/Gastroenterology, Tulane University Health Sciences Center, New Orleans, Louisiana, United States; VA Medical Center, Louisiana, United States
* To whom correspondence should be addressed. E-mail: ntobey{at}tulane.edu.
Objectives: The human esophagus is lined by stratified squamous epithelium (ESSE), and in some subjects with reflux disease, the distal esophagus becomes lined by Barrett's specialized columnar epithelium (BSCE). ESSE and BSCE differ both histologically and functionally, the latter evident by differences in their in vivo transmural electrical potential difference (PD) - ESSE averaging -15 mV and BSCE being >-25 mV. In this report we examine the basis for this difference in PD. Methods: This is done by mounting endoscopic biopsies of ESSE from 25 subjects without esophageal disease and BSCE from 19 with Barrett's esophagus in mini-Ussing chambers for electrical recordings basally and after bathing solution ion replacement. Results: The results show that the PD of human ESSE reflects a low level of active ion transport (5.1±0.8 µAmps/cm2) combined with high level of tissue (electrical) resistance (344±34 ohm.cm2) and that of BSCE reflects a high level of active transport (43.6±11.6 µAmps/cm2) combined with low level of resistance (69±8 ohm.cm2). Further, active transport in ESSE was principally due to sodium absorption while in BSCE it was equally divided between sodium absorption and anion (chloride/bicarbonate) secretion, the latter through an apical membrane, SITS-sensitive, anion channel. Conclusion: BSCE, as anion secreting tissue with bicarbonate secretory capacity more than 5-fold greater than ESSE, supports BSCE as better suited than ESSE for defense of the esophagus against reflux disease.
This article has been cited by other articles:
|
|
 |
|
  A. Casselbrant, A. Edebo, P. Hallersund, E. Spak, H. F. Helander, C. Jonson, and L. Fandriks Angiotensin II receptors are expressed and functional in human esophageal mucosa Am J Physiol Gastrointest Liver Physiol, November 1, 2009; 297(5): G1019 - G1027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y Akiba, M Mizumori, M Kuo, M Ham, P H Guth, E Engel, and J D Kaunitz CO2 chemosensing in rat oesophagus Gut, December 1, 2008; 57(12): 1654 - 1664. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 X. Li, P. C. Galipeau, C. A. Sanchez, P. L. Blount, C. C. Maley, J. Arnaudo, D. A. Peiffer, D. Pokholok, K. L. Gunderson, and B. J. Reid Single Nucleotide Polymorphism-Based Genome-Wide Chromosome Copy Change, Loss of Heterozygosity, and Aneuploidy in Barrett's Esophagus Neoplastic Progression Cancer Prevention Research, November 1, 2008; 1(6): 413 - 423. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Reid Cancer Risk Assessment and Cancer Prevention: Promises and Challenges Cancer Prevention Research, September 1, 2008; 1(4): 229 - 232. [Full Text] [PDF]
|
|
|
|
|
|
B. Jovov, C. M. Van Itallie, N. J. Shaheen, J. L. Carson, T. M. Gambling, J. M. Anderson, and R. C. Orlando Claudin-18: a dominant tight junction protein in Barrett's esophagus and likely contributor to its acid resistance Am J Physiol Gastrointest Liver Physiol, December 1, 2007; 293(6): G1106 - G1113. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
