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Am J Physiol Gastrointest Liver Physiol (May 18, 2006). doi:10.1152/ajpgi.00073.2006
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Submitted on February 17, 2006
Accepted on February 27, 2006

Bitter taste receptors and alpha-gustducin in the mammalian gut

Enrique Rozengurt1*

1 Division of Digestive Diseases and CURE: Digestive Research Center, David Geffen School of Medicine, University of California at Los Angles, Los Angeles, California, United States

* To whom correspondence should be addressed. E-mail: erozengurt{at}mednet.ucla.edu.

Molecular sensing by gastrointestinal (GI) cells plays a critical role in the control of multiple fundamental functions in digestion and also initiates hormonal and/or neural pathways leading to the regulation of caloric intake, pancreatic insulin secretion and metabolism. Molecular sensing in the GI tract is also responsible for the detection of ingested harmful drugs and toxins thereby initiating responses critical for survival. The initial recognition events and mechanism(s) involved remain incompletely understood. The notion to be discussed in this article is that there are important similarities between the chemosensensory machinery elucidated in specialized neuroepithelial taste receptor cells of the lingual epithelium and the molecular transducers localized recently in enteroendocrine open GI cells that sense the chemical composition of the luminal contents of the gut.




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