AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol (June 5, 2002). doi:10.1152/ajpgi.00089.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/4/G875    most recent
00089.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Williams, K. L
Right arrow Articles by Lund, P. K.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Williams, K. L
Right arrow Articles by Lund, P. K.

Articles in PresS, published online ahead of print June 5, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00089.2002
Submitted on March 4, 2002
Accepted on June 3, 2002

Mesenchymal IGF-I overexpression: paracrine effects in the intestine, distinct from endocrine actions

Kristen L Williams1*, C. Randall Fuller2, James Fagin3, and Pauline Kay Lund2

1 Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA; Department of Medicine, University of North Carolina, Chapel Hill, NC, USA
2 Department of Cell and Molecular Physiology, University of North Carolina, Chapel Hill, NC, USA
3 Division of Endocrinology and Metabolism, University of Cincinnati, Cincinnati, OH, USA

* To whom correspondence should be addressed. E-mail: kristen_williams{at}med.unc.edu.

Local IGF-I expression is frequently increased in intestinal mesenchyme during adaptive growth of intestinal epithelium, but paracrine growth effects of IGF-I in vivo are not defined. We tested whether overexpression of IGF-I in intestinal mesenchyme increases epithelial growth and if effects are distinct from known effects of circulating IGF-I. SMP8-IGF-I transgenic mice (SMP8-IGF-I-TG) overexpress IGF-I driven by an alpha smooth muscle actin promoter. Mucosal and muscularis growth were assessed in the jejunum, ileum, and colon of SMP8-IGF-I-TG and wild type littermates. Abundance of the SMP8-IGF-I transgene and IGF binding protein (IGFBP)-3 and -5 mRNAs was determined. Mucosal growth was increased in SMP8-IGF-I-TG ileum but not jejunum or colon; muscularis growth was increased throughout the bowel. IGFBP-5 mRNA was increased in SMP8-IGF-I-TG jejunum and ileum and was specifically upregulated in ileal lamina propria. Overexpression of IGF-I in intestinal mesenchymal cells has preferential paracrine effects on the ileal mucosal epithelium and autocrine effects on the muscularis throughout the bowel. Locally expressed IGF-I has distinct actions on IGFBP expression compared with circulating IGF-I.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. W. Nelson, S. G. Murali, X. Liu, M. C. Koopmann, J. J. Holst, and D. M. Ney
Insulin-like growth factor I and glucagon-like peptide-2 responses to fasting followed by controlled or ad libitum refeeding in rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1175 - R1184.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. G. Simmons, Y. Ling, H. Wilkins, C. R. Fuller, A. J. D'Ercole, J. Fagin, and P. K. Lund
Cell-specific effects of insulin receptor substrate-1 deficiency on normal and IGF-I-mediated colon growth
Am J Physiol Gastrointest Liver Physiol, November 1, 2007; 293(5): G995 - G1003.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
S. G. Murali, X. Liu, D. W. Nelson, A. K. Hull, M. Grahn, M. K. Clayton, J. E. Pintar, and D. M. Ney
Intestinotrophic effects of exogenous IGF-I are not diminished in IGF binding protein-5 knockout mice
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2007; 292(6): R2144 - R2150.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
F Rieder, J Brenmoehl, S Leeb, J Scholmerich, and G Rogler
Wound healing and fibrosis in intestinal disease
Gut, January 1, 2007; 56(1): 130 - 139.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Z. Michaylira, J. G. Simmons, N. M. Ramocki, B. P. Scull, K. K. McNaughton, C. R. Fuller, and P. K. Lund
Suppressor of cytokine signaling-2 limits intestinal growth and enterotrophic actions of IGF-I in vivo
Am J Physiol Gastrointest Liver Physiol, September 1, 2006; 291(3): G472 - G481.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Bellier, N. R. Da Silva, G. Aubin-Houzelstein, C. Elbaz, J.-M. Vanderwinden, and J.-J. Panthier
Accelerated intestinal transit in inbred mice with an increased number of interstitial cells of Cajal
Am J Physiol Gastrointest Liver Physiol, January 1, 2005; 288(1): G151 - G158.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. F. Kuemmerle, K. S. Murthy, and J. G. Bowers
IGFBP-3 activates TGF-{beta} receptors and directly inhibits growth in human intestinal smooth muscle cells
Am J Physiol Gastrointest Liver Physiol, October 1, 2004; 287(4): G795 - G802.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. W. Knott, R. J. Juno, M. D. Jarboe, S. A. Profitt, C. R. Erwin, E. P. Smith, J. A. Fagin, and B. W. Warner
Smooth muscle overexpression of IGF-I induces a novel adaptive response to small bowel resection
Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G562 - G570.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1979 by the American Physiological Society.