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Articles in PresS, published online ahead of print May 29, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00101.2002
Submitted on March 14, 2002
Accepted on May 29, 2002
1 Department of Physiology, University of Nevada, Reno, NV, USA
* To whom correspondence should be addressed. E-mail: burt{at}physio.unr.edu.
Calmodulin (CaM) plays important roles for contractile activity in smooth muscles. Recently, two distinct Ca2+-binding protein superfamilies with sequence similarities to CaM have been identified in neuronal cells: neuronal Ca2+-binding proteins (NCBPs) and CaM-like Ca2+-binding proteins (CaBPs). Some NCBPs and CaBPs play significant roles for Ca2+-dependent cellular signaling in the nervous system. In gastrointestinal smooth muscles (GISMs), CaM functions as the regulator of contractile behavior and electrical rhythmicity. However, the molecular identification of NCBPs and CaBPs has not been elucidated in GISMs. Here we have identified NCBPs and CaBPs expressed in GISMs and determined the expression levels of their transcripts by quantitative RT-PCR. Of 12 NCBPs, the transcripts for neuronal Ca2+ sensor 1 (NCS1), neural visinin-like protein 1 (NVP1), NVP2, NVP3, K+ channel-interacting protein 1 (KChIP1), and KChIP3 were detected in proximal colon, gastric fundus, gastric antrum, and jejunum. On the other hand, of 7 CaBPs including alternatively spliced variants, only CaBP1L transcripts were detected in GISMs.
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