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Am J Physiol Gastrointest Liver Physiol (June 5, 2002). doi:10.1152/ajpgi.00105.2002
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Articles in PresS, published online ahead of print June 5, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00105.2002
Submitted on March 18, 2002
Accepted on May 30, 2002

Primary Sensory Neurons--A Common Final Pathway for Inflammation in Experimental Pancreatitis in Rats

Jaimie D Nathan1, Ruth Y Peng2, Yu Wang3, Douglas C McVey4, Steven R Vigna5, and Rodger A Liddle4*

1 Department of Surgery, Duke University Medical Center, Durham, NC, USA
2 Department of Pathology, Duke University Medical Center, Durham, NC, USA
3 Department of Medicine, Duke University Medical Center, Durham, NC, USA
4 Department of Medicine, Duke University Medical Center, Durham, NC, USA; Veterans Affairs Medical Center, Durham, NC, USA
5 Department of Medicine, Duke University Medical Center, Durham, NC, USA; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA; Veterans Affairs Medical Center, Durham, NC, USA

* To whom correspondence should be addressed. E-mail: liddl001{at}mc.duke.edu.

We hypothesized that neurogenic inflammation is a common final pathway for parenchymal inflammation in pancreatitis, and evaluated the role of primary sensory neurons in secretagogue-induced and obstructive pancreatitis. Neonatal rats received either the primary sensory neuron-denervating agent capsaicin (50 mg/kg SC) or vehicle. At 8 weeks of age, pancreatitis was produced by 6 hourly injections of caerulein (50 µg/kg IP) or by common pancreaticobiliary duct ligation (CPBDL). The severity of pancreatitis was assessed by serum amylase, pancreatic myeloperoxidase (MPO) activity, histological grading, pancreatic plasma extravasation, and wet-to-dry weight ratio. Caerulein significantly increased MPO activity and wet-to-dry weight ratio, produced histological evidence of edematous pancreatitis, induced plasma extravasation, and caused hyperamylasemia. CPBDL increased MPO activity and produced histological evidence of pancreatitis. Neonatal capsaicin administration significantly reduced tissue MPO levels, histological severity scores, and wet-to-dry weight ratio, and abolished plasma extravasation. These results demonstrate that primary sensory neurons play a significant role in the inflammatory cascade in experimental pancreatitis, and appear to constitute a common final pathway for pancreatic parenchymal inflammation.




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