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Am J Physiol Gastrointest Liver Physiol (October 17, 2001). doi:10.1152/ajpgi.00114.2001
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Articles in PresS, published online ahead of print October 15, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00114.2001
Submitted on March 20, 2001
Accepted on October 9, 2001

Cholinergic and nitrergic regulation of in vivo giant migrating contractions in rat colon

Mona Li1, Christopher P Johnson1, Mark B Adams1, and Sushil K Sarna2*

1 Surgery and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
2 Surgery and Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin, USA; Zablocki VA Medical Center, Milwaukee, Wisconsin, USA

* To whom correspondence should be addressed. E-mail: ssarna{at}mcw.edu.

The aim of this study was to characterize in vivorat colonic motor activity in the normal and the inflamed states and determine its neural regulation. Circular muscle contractions were recorded by surgically implanted strain gauge transducers. The rat colon exhibited predominantly giant migrating contractions (GMCs) whose frequency decreased distally. Only a small percent of these GMCs propagated in the distal direction. The phasic contractions were present, but their amplitude was very small as compared with that of GMCs. Inflammation induced by oral administration of dextran sodium sulfate suppressed the frequency of GMCs in the proximal and the middle, but not in the distal colon. The frequency of GMCs was suppressed by atropine and 4-DAMP, and enhanced by L-NAME. Serotonin, tachykinin and CGRP receptor antagonists as well as guanethidine and suramin had no significant effect on the frequency of GMCs. High doses of verapamil transiently suppressed the GMCs. In conclusion, unlike the canine and human colons, the rat colon exhibits frequent GMCs and their frequency is suppressed in inflammation. The in vivo GMCs are stimulated by neural release of acetylcholine that acts on M3 receptors. Constitutive release of NO may partially suppress their frequency.




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