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1 Program in Neuroscience, Department of Veterinary and Comparative Anatomy, Pharmacology, and Physiology, Washington State University, College of Veterinary Medicine, Pullman, WA, USA
* To whom correspondence should be addressed. E-mail: simasko{at}vetmed.wsu.edu.
Patch-clamp electrophysiological methods were used on dissociated rat nodose neurons maintained in culture to determine if responses to cholecystokinin (CCK) were associated with A-type or C-type neurons. Nodose neurons were classified as A-type or C-type based on the characteristics of the Na+ current and Ih they expressed, and their sensitivity to a low concentration of capsaicin to ascertain the presence of VR1 receptors that have been associated with C-type neurons in sensory ganglia. It was expected that only capsaicin-sensitive C-type neurons would respond to CCK since most vagal mediated actions of CCK are blocked by capsaicin treatment. However, we found that a subpopulation of both A-type (capsaicin resistant) and C-type (capsaicin sensitive) neurons responded to CCK (24% and 38%, respectively). Thus some vagal mediated actions of CCK may be mediated by capsaicin insensitive A-type neurons.
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