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Am J Physiol Gastrointest Liver Physiol (December 5, 2001). doi:10.1152/ajpgi.00134.2001
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Articles in PresS, published online ahead of print December 5, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00134.2001
Submitted on March 29, 2001
Accepted on November 29, 2001

IDENTIFICATION OF BIOMECHANICAL FACTORS ASSOCIATED WITH THE PERCEPTION OF DISTENSION IN THE HUMAN ESOPHAGUS

Josephine D Barlow1, Hans Gregersen2, and David G Thompson1*

1 GI Science, University of Manchester, Salford, Lancashire, United Kingdom
2 Centre for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark

* To whom correspondence should be addressed. E-mail: jbarlow{at}fs1.ho.man.ac.uk.

The current techniques used to investigate the mechanisms responsible for the sensory responses to distension of the human esophagus provide limited information, as the degree of circumferential stretch required to determine tension can only be inferred. We used impedance planimetry to measure the cross-sectional area during esophageal distension, in order to ascertain the degree of stretch and tension that initiated motor and sensory responses. Hyoscine-N-butyl bromide (HBB), a cholinergic muscarinic receptor blocker, was also used to alter esophageal tension during distension. Motor activity was initiated at a lower degree of stretch and tension than that which initiated sensory awareness, both increased directly with increasing distension. HBB reduced both esophageal motility and tension during distension without altering the relationship between sensation intensity and cross sectional area. Eesophageal stretch rather than tension thus appears to be the major factor influencing sensory responses to oesophageal distension.




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