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Am J Physiol Gastrointest Liver Physiol (March 28, 2002). doi:10.1152/ajpgi.00149.2001
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Articles in PresS, published online ahead of print March 28, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00149.2001
Submitted on April 10, 2001
Accepted on March 13, 2002

THE ROLE OF TUMOR NECROSIS FACTOR-ALPHA IN GUT MUCOSAL CHANGES AFTER SEVERE BURN

Marcus Spies1, Vicky L Chappell1, Mohan R Dasu1, David N Herndon2, James C Thompson2, and Steven E Wolf2*

1 Shriners Hospitals for Children, Galveston, Texas, USA
2 Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA

* To whom correspondence should be addressed. E-mail: swolf{at}utmb.edu.

Gut epithelial cell death by apoptosis is increased in the gut epithelium after severe burn, which is associated with mucosal atrophy. We hypothesized that TNF-{alpha}/TNFR interaction activates apoptosis in small bowel mucosal cells after severe burn. C57BL6 mice received a 30% TBSA scald burn and were treated with neutralizing anti-TNF-{alpha}. The proximal small bowel was assessed for mucosal atrophy. Proliferation and apoptosis of mucosal cells were assessed by PNCA-immunostaining and TUNEL-assay, respectively. Mucosal height and mucosal cell number decreased after burn. Anti-TNF-{alpha} treated mice showed significantly less mucosal atrophy. Proliferation of intestinal cells was not changed with burn or anti-TNF-{alpha} treatment. An over 3-fold increase in apoptotic cell number was seen after burn, which was diminished by anti-TNF-{alpha} treatment. Changes in gut mucosal homeostasis after severe burn are affected in part by the activation of apoptosis by TNF/TNFR interaction.




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