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Articles in PresS, published online ahead of print August 7, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00154.2002
Submitted on April 26, 2002
Accepted on July 25, 2002
1 Department of Medicine, Division of Digestive Diseases and Brain Research Institute, CURE:DDRC, UCLA, Los Angeles, CA, USA
* To whom correspondence should be addressed. E-mail: ytache{at}ucla.edu.
The influence of intravenous (iv) peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125 and 250 pmol/kg/h) significantly reduced gastric lesions by 36%, 59%, 40% and 38% respectively. Antibody against rat PYY injected iv (2 mg/kg) completely prevented the gastroprotective effect of iv PYY (75 pmol/kg/h), while injected intracisternally (ic, 460 µg/ 20 µl), it significantly prevented ic PYY (24 pmol/rat)-induced 58% reduction of ethanol lesions but not that induced by iv PYY. Vagotomy did not influence the gastroprotective effect of iv PYY. The Y1/"PYY-preferring" receptor agonist, [Pro34] PYY (75 pmol/kg/h, iv) significantly decreased ethanol-induced gastric lesions by 82%, while [Leu31, Pro34]NPY, a Y1/Y3 agonist, and PYY3-36, a Y2 agonist, had no effect. These data indicate that PYY infused iv at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors.
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