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Am J Physiol Gastrointest Liver Physiol (August 7, 2002). doi:10.1152/ajpgi.00154.2002
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Articles in PresS, published online ahead of print August 7, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00154.2002
Submitted on April 26, 2002
Accepted on July 25, 2002

Gastric protective effect of peripheral PYY through PYY preferring receptors in anesthetized rats

Keishi Kawakubo1, Hong Yang1, and Yvette Tache1*

1 Department of Medicine, Division of Digestive Diseases and Brain Research Institute, CURE:DDRC, UCLA, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: ytache{at}ucla.edu.

The influence of intravenous (iv) peptide YY (PYY) on the gastric injury induced by 45% ethanol was investigated in urethane-anesthetized rats. PYY (25, 75, 125 and 250 pmol/kg/h) significantly reduced gastric lesions by 36%, 59%, 40% and 38% respectively. Antibody against rat PYY injected iv (2 mg/kg) completely prevented the gastroprotective effect of iv PYY (75 pmol/kg/h), while injected intracisternally (ic, 460 µg/ 20 µl), it significantly prevented ic PYY (24 pmol/rat)-induced 58% reduction of ethanol lesions but not that induced by iv PYY. Vagotomy did not influence the gastroprotective effect of iv PYY. The Y1/"PYY-preferring" receptor agonist, [Pro34] PYY (75 pmol/kg/h, iv) significantly decreased ethanol-induced gastric lesions by 82%, while [Leu31, Pro34]NPY, a Y1/Y3 agonist, and PYY3-36, a Y2 agonist, had no effect. These data indicate that PYY infused iv at doses reported to mimic postprandial peak blood levels prevents ethanol-induced gastric injury through vagal independent pathways and PYY-preferring receptors.




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