It is well known that transfer of CD4⁺CD45RB^high (naive) T-cells into syngeneic lymphocyte-deficient mice induces chronic colitis. However, no studies have reported the presence of small bowel inflammation in this T-cell-dependent model. Therefore, the objective of this study was to evaluate and compare the small and large bowel inflammation induced by transfer of naïve T-cells into two different immuno-deficient recipient mice. T- and B-cell deficient recombinase activating gene-1 deficient mice (RAG KO) and T-cell deficient T-cell receptor X double-deficient (TCR KO) mice were reconstituted with wild-type naive T cells and observed for signs of disease. We found that reconstituted RAG KO mice developed moderate-to-severe colitis and inflammation of the entire small intestine at 6-8 weeks following T-cell transfer. Adoptive transfer of naive T-cells into TCR KO induced a milder form of chronic colitis and small bowel inflammation that was confined primarily to the duodenum at 10-12 weeks following T-cell transfer. T-helper cell-1 (Th1) and macrophage-derived pro-inflammatory cytokine mRNA levels correlated well with the localization and severity of the chronic large and small bowel inflammation. In addition, we observed comparable homing and expansion of donor lymphocytes in the gut and secondary lymphoid tissues of both recipients. Taken together, our data demonstrate that transfer of naive T-cells into immunodeficient recipient mice induces both chronic small and large bowel inflammation and that the presence of B-cells in the TCR KO recipients may play a role in regulating chronic intestinal inflammation.