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Am J Physiol Gastrointest Liver Physiol (August 28, 2002). doi:10.1152/ajpgi.00222.2002
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Articles in PresS, published online ahead of print August 28, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00222.2002
Submitted on June 10, 2002
Accepted on August 27, 2002

The cephalic phase of acid secretion involves activation of medullary TRH receptor subtype 1 in rats

Vicente Martinez1, Maria-Dolores Barrachina1, Gordon Ohning1, and Yvette Tache1*

1 Department of Medicine, University of California at Los Angeles, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: ytache{at}ucla.edu.

Mechanisms involved in the cephalic phase of gastric acid secretion were studied in awake fasted rats with chronic gastric fistula and exposed to the sight and smell of chow for 30 min. Acid secretion was monitored using constant intragastric perfusion and automatic titration. Sham-feeding induced a peak acid response reaching 82 ± 7 µmol/10 min within 20 min compared with the average 22 ± 2 µmol/10 min in controls. The sham-feeding response was abolished by intracisternal pretreatment with the TRH1 receptor antisense oligodeoxynucleotides or subcutaneous injection of atropine while TRH1 mismatch oligodeoxynucleotides had no effect. Serum gastrin was not altered by the sham-feeding and increased by refeeding. Gastrin antibody did not block the rise in acid during sham-feeding although the net acid response was reduced by 47% compared with the control group. Gly-gastrin antibody, indomethacin and L-NAME had no effect. Atropine and gastrin antibody decreased basal acid secretion by 98% and 75% respectively while all other pretreatments did not. These results indicate that the cholinergic dependent acid response to sham-feeding is mediated by brain medullary TRH1 receptors in rats.






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