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Am J Physiol Gastrointest Liver Physiol (October 3, 2001). doi:10.1152/ajpgi.00240.2001
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Articles in PresS, published online ahead of print October 3, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00240.2001
Submitted on June 7, 2001
Accepted on September 21, 2001

NEONATAL MATERNAL SEPARATION ALTERS STRESS-INDUCED RESPONSES TO VISCEROSOMATIC NOCICEPTIVE STIMULI IN THE ADULT RAT

Santosh V Coutinho1, Paul M Plotsky2, Marciano R Sablad1, Jerry C Miller1, Huping Zhou1, Alfred I Bayati3, James A McRoberts1, and Emeran A Mayer4*

1 Department of Medicine, Neuroenteric Disease Program, UCLA School of Medicine, Los Angeles, CA, USA
2 Department of Psychiatry, Stress Neurobiology Laboratory, Emory University, Atlanta, GA, USA
3 AstraZeneca R&D, Molndal, Sweden
4 Department of Medicine, Neuroenteric Disease Program, UCLA School of Medicine, Los Angeles, CA, USA; Department of Physiology, UCLA School of Medicine, Los Angeles, CA, USA; Department of Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, CA, USA

* To whom correspondence should be addressed. E-mail: emayer{at}ucla.edu.

This study investigated the combined effect of neonatal maternal separation and acute psychological stress on pain responses in adult rats. Long Evans dams and their male pups were reared under two conditions: 1) 180 min daily maternal separation (MS180) from post-natal day 2-14; or 2) no handling (NH) or separation. At 2 months of age, visceromotor responses to graded intensities of phasic colorectal distension (CRD; 10-80 mmHg) at baseline as well as following acute 60 min water avoidance (WA) stress were significantly higher in MS180 rats. Both groups showed similar stress-induced visceral hyperalgesia in the presence of naloxone (20 mg/kg, i.p.). MS180 rats had smaller stress-induced cutaneous analgesia in the tail flick test compared to NH rats, with a residual naloxone-resistant component. MS180 rats showed an enhanced fecal pellet output following WA or exposure to a novel environment. These data suggest that early life events predispose adult Long Evans rats to develop visceral hyperalgesia, reduced somatic analgesia, and increased colonic motility in response to an acute psychological stressor, mimicking the cardinal features of IBS.






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