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Am J Physiol Gastrointest Liver Physiol (October 31, 2001). doi:10.1152/ajpgi.00262.2001
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Articles in PresS, published online ahead of print October 31, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00262.2001
Submitted on June 18, 2001
Accepted on October 7, 2001

Ontogenetic Expression and Regulation of Na+/D-Glucose Cotransporter in the Jejunum of the Domestic Chicken

Anna Barfull1, Carles Garriga1, Montserrat Mitjans1, and Joana M Planas1*

1 Departament de Fisiologia Divisio-IV, Facultat de Farmacia, Universitat de Barcelona, Barcelona, Barcelona, Spain

* To whom correspondence should be addressed. E-mail: jplanas{at}farmacia.far.ub.es.

To evaluate the effect of age on sugar transport, the uptake of {alpha}-methyl-D-glucoside and the abundance of the Na+/D-glucose cotransporter (SGLT1) were determined in jejunal brush-border membrane (BBM) vesicles of 2-day- and 5-week-old chickens. {alpha}-Methyl-D-glucoside transport per BBM protein was 40% lower in adults than in newly hatched chickens. This finding was matched by parallel declines in site density of SGLT1, detected by Western blot. The immunohistochemical study showed that SGLT1 was exclusively located in the BBM of enterocytes along the entire villus, was absent in the crypt in both age-groups, and that there was an 11-fold increase in the total absorptive area during development. Northern blot studies of the abundance of SGLT1 mRNA showed similar levels for the groups studied. We conclude that the age-related decline in Na+-dependent hexose transport per unit BBM protein in the chicken jejunum is due to a reduction in the density of SGLT1 cotransporter, and is regulated by a post-transcriptional mechanism.




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