| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Articles in PresS, published online ahead of print October 10, 2001
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00264.2001
Submitted on June 18, 2001
Accepted on October 4, 2001
1 Pharmacology, LSUHSC, New Orleans, LA, USA
2 Neurobiology, PBRC, Baton Rouge, LA, USA
* To whom correspondence should be addressed. E-mail: phornb{at}lsuhsc.edu.
Orexins regulate food intake, arousal and the sleep/wake cycle. They are synthesized by neurons in the lateral hypothalamus and project to autonomic areas in the hindbrain. Orexin-A applied to the dorsal surface of the medulla stimulates gastric acid secretion via a vagally-mediated pathway. We tested the hypothesis that orexins in the dorsal motor nucleus of the vagus (DMN) regulate gastric motor function. Multibarelled micropipette assemblies were used to administer vehicle, L-glutamate, orexin-A (1 and 10 pmol), orexin-B (10 pmol) and a dye marker into this site in anesthetized rats. When the pipette was positioned in the DMN rostral to the obex (where excitation of neurons by L-glutamate evoked an increase in contractility), orexin-A and orexin-B increased intragastric pressure and antral motility. In contrast, 10 pmol orexin-A microinjected into the DMN caudal to the obex (where L-glutamate evokes gastric relaxation through a vagal inhibitory pathway) did not significantly alter gastric motor function. In separate immunocytochemical studies, orexin receptor 1 (OR1) was highly expressed in neurons in the DMN. Specifically, it was present in retrogradely-labeled preganglionic neurons in the DMN which innervate the stomach. These data are consistent with the idea that orexin-A stimulates vagal excitatory motor neurons. These are the first data to suggest that orexins in the DMN have potent and long-lasting effects to increase gastric contractility.
This article has been cited by other articles:
|
|
 |
|
  S.-Y. Zhou, Y.-X. Lu, H. Yao, and C. Owyang Spatial organization of neurons in the dorsal motor nucleus of the vagus synapsing with intragastric cholinergic and nitric oxide/VIP neurons in the rat Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1201 - G1209. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Cruz, E. C. Murphy, N. Sahibzada, J. G. Verbalis, and R. A. Gillis A reevaluation of the effects of stimulation of the dorsal motor nucleus of the vagus on gastric motility in the rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R291 - R307. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Kobashi, Y. Shimatani, K. Shirota, S.-Y. Xuan, Y. Mitoh, and R. Matsuo Central neuropeptide Y induces proximal stomach relaxation via Y1 receptors in the dorsal vagal complex of the rat Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2006; 290(2): R290 - R297. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Shi, A. R. Jones, M. Ferreira Jr, N. Sahibzada, R. A. Gillis, and J. G. Verbalis Glucose does not activate nonadrenergic, noncholinergic inhibitory neurons in the rat stomach Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2005; 288(3): R742 - R750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Grabauskas, S.-Y. Zhou, S. Das, Y. Lu, C. Owyang, and H. C Moises Prolactin-releasing peptide affects gastric motor function in rat by modulating synaptic transmission in the dorsal vagal complex J. Physiol., December 15, 2004; 561(3): 821 - 839. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Davis, K. W. Williams, W. Xu, N. R. Glatzer, and B. N. Smith Selective Enhancement of Synaptic Inhibition by Hypocretin (Orexin) in Rat Vagal Motor Neurons: Implications for Autonomic Regulation J. Neurosci., May 1, 2003; 23(9): 3844 - 3854. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
