Submitted on June 20, 2006
Accepted on July 7, 2006
Flagellin induced inflammation and anti-apoptosis
Andrew Neish1*
1 Pathology, Emory University, Atlanta, Georgia, United States
* To whom correspondence should be addressed. E-mail: aneish{at}emory.edu.
Flagellin is bacterial protein that serves as a danger signal across a wide variety of eukaryotes, and is a potent inducer of inflammatory effector responses in the mammalian gut. Recent findings utilizing purified flagellin and flagellate/aflagellate bacteria in in vitro and in vivo systems reveals important roles played by flagellin in the initial encounter between mucosa and flagellate bacteria, specifically in the modulation of apoptotic responses.
