AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol (March 19, 2003). doi:10.1152/ajpgi.00280.2002
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/1/G96    most recent
00280.2002v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by De Ponti, F.
Right arrow Articles by Crema, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by De Ponti, F.
Right arrow Articles by Crema, A.
Submitted on July 12, 2002
Accepted on March 18, 2003

Role of 5-HT1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists

Fabrizio De Ponti1*, Francesca Crema2, Elisabetta Moro2, Giuseppe Nardelli2, Gianmario Frigo2, and Antonio Crema2

1 Department of Pharmacology, University of Bologna, Bologna, BO, Italy
2 Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, PV, Italy

* To whom correspondence should be addressed. E-mail: deponti{at}biocfarm.unibo.it.

Role of 5-HT1B/D receptors in gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. - The 5-HT1B/D receptor agonist sumatriptan has been proposed to treat dyspeptic symptoms because it facilitates gastric accommodation. It is unknown whether stimulation of 5-HT1B/D receptors is involved. Thus, in four conscious dogs, we compared the effects of sumatriptan alone or combined with GR127935, SB216641 or BRL15572 (respectively, non selective 5-HT1B/D, selective 5-HT1B and selective 5-HT1D receptor antagonists) on gastric accommodation to isobaric distensions performed with a barostat. An exponential and a linear model were used to fit the pressure-volume relationship. An exponential equation fitted the data better than a linear equation. Sumatriptan (800 nmol.kg-1 i.v.) induced an immediate gastric relaxation ({Delta}volume: 112±44 ml, P <0.05). After sumatriptan, the pressure-volume curve was shifted towards significantly higher volumes. This effect was fully reversed by GR127935 or SB216641, but not by BRL15572. In conclusion, 5-HT1B receptors seem to play an important role in modulating gastric accommodation to a distending stimulus. An exponential model for pressure-volume curves fits well with the concept of gastric adaptive relaxation.




This article has been cited by other articles:


Home page
 GutHome page
S Kindt and J Tack
Impaired gastric accommodation and its role in dyspepsia
Gut, December 1, 2006; 55(12): 1685 - 1691.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
L. Xue, G. R. Locke, M. Camilleri, J. A. J. Schuurkes, A. Meulemans, B. J. Coulie, J. H. Szurszewski, and G. Farrugia
Effect of modulation of serotonergic, cholinergic, and nitrergic pathways on murine fundic size and compliance measured by ultrasonomicrometry
Am J Physiol Gastrointest Liver Physiol, January 1, 2006; 290(1): G74 - G82.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Janssen, N. H. Prins, B. Moreaux, A. L. Meulemans, and R. A. Lefebvre
Characterization of 5-HT7-receptor-mediated gastric relaxation in conscious dogs
Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G108 - G115.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1979 by the American Physiological Society.