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1 Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA
2 Department of Pathology and Laboratory Medicine, University of Wisconsin Hospitals and Clinics, Madison, WI, USA
3 Department of Medical Physiology, University of Copenhagen-Denmark, Copenhagen, Denmark
* To whom correspondence should be addressed. E-mail: ney{at}nutrisci.wisc.edu.
To elucidate the role of luminal nutrients and GLP-2 in intestinal adaptation, rats were subjected to 70% mid jejunoileal resection (R) or ileal transection (T) and maintained with total parenteral nutrition (TPN) or oral feeding. TPN rats showed small bowel mucosal hyperplasia at 8 hours through 7 days after R, demonstrating that exogenous luminal nutrients are not essential for resection-induced adaptation when residual ileum and colon are present. Increased enterocyte proliferation was a stronger determinant of resection-induced mucosal growth in orally fed animals whereas decreased apoptosis showed a greater effect in TPN animals. TPN induced significant transient increases in plasma bioactive GLP-2 whereas oral feeding induced sustained increases in plasma GLP-2 after R. Resection-induced adaptive growth in TPN and orally fed rats was associated with a significant positive correlation between increases in plasma bioactive GLP-2 and proglucagon mRNA expression in the colon of TPN rats and ileum of orally fed rats. These data support a significant role for endogenous GLP-2 in the adaptive response to resection in both TPN and orally fed rats.
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