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Am J Physiol Gastrointest Liver Physiol (July 12, 2007). doi:10.1152/ajpgi.00298.2007
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Submitted on June 29, 2007
Accepted on July 9, 2007

Invariant NKT Cells and Liver Diseases: Is there Strength in Numbers?

MAUREEN N. AJUEBOR1*

1 PHYSIOLOGY, LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER, SHREVEPORT, Louisiana, United States

* To whom correspondence should be addressed. E-mail: MAJUEB{at}LSUHSC.EDU.

Information regarding the functional role of the innate immune T cell, invariant NKT (iNKT) cells, in the pathophysiology of liver diseases continues to emerge. Results from animal studies suggest that iNKT cells can have divergent roles by specifically promoting the development of pro-inflammatory or anti-inflammatory responses in liver diseases. In this themes article, I discuss the critical evidence from animal models that demonstrate a vital role for iNKT cells in the pathophysiology of liver diseases with emphasis on viral, autoimmune and toxin-induced liver diseases. Further, I discuss the controversial issues (including iNKT cell apoptosis) that typify some of these studies. Finally, I highlight areas that require additional investigation.




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