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Am J Physiol Gastrointest Liver Physiol (July 12, 2007). doi:10.1152/ajpgi.00299.2007
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Submitted on July 2, 2007
Accepted on July 5, 2007

Dietary Lipid Absorption, Complex Lipid Synthesis, and the Intracellular Packaging and Secretion of Chylomicrons

Charles M. Mansbach1* and Fred Gorelick2

1 Medicine/GI, University of Tennessee, Memphis, Tennessee, United States
2 Yale University, West Haven, Connecticut, United States

* To whom correspondence should be addressed. E-mail: cmansbach{at}utmem.edu.

Research in dietary fat absorption has developed urgency because of the widely recognized epidemic of obesity in the United States. Despite its clinical importance, many controversies exist over some of the basic aspects of this process from the mechanisms of fatty acid uptake to the control of triacylglycerol export in chylomicrons. Recent advances have included the identification of a number of fatty acid transporters, the discovery of families of acyl-CoA synthetase long chains and acyltransferases, a physiological function for liver-fatty acid binding protein, and the characterization of the pre-chylomicron transport vesicle transporting chylomicrons from the ER to the Golgi.




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