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Articles in PresS, published online ahead of print November 20, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00324.2002
Submitted on August 5, 2002
Accepted on November 12, 2002
1 Department of Pharmacology, University of Iowa, College of Medicine, Iowa City, IA, USA
* To whom correspondence should be addressed. E-mail: gf-gebhart{at}uiowa.edu.
Colorectal distension (CRD) is a well-characterized model of visceral nociception which we adapted to the mouse. CRD reproducibly evoked contractions of the abdominal musculature (visceromotor response, VMR) that was graded to stimulus intensity. The magnitude of the VMR was greater in male C57BL6 and female 129S6 mice than in male 129S6 and B6.129 mice. In 129S6, C57BL6 and B6.129 mouse strains, the VMR was reduced dose-dependently by morphine (1-10 mg/kg) and by the kappa opioid agonist U69,593 (0.2-2 mg/kg), although U69,593 was significantly less potent in C57BL6 mice. In additional experiments, the VMR was recorded from adult male 129S6 mice before and after intracolonic administration of various irritants. Only 30% ethanol significantly enhanced responses to CRD. The colon hyperalgesia persisted for 14 days and was associated with a significant shift of the morphine dose-response function to the left. We believe this will be a useful model for study of visceral nociception and hyperalgesia, including studies of transgenic mice with mutations relevant to pain.
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