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Am J Physiol Gastrointest Liver Physiol (February 27, 2002). doi:10.1152/ajpgi.00348.2001
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Articles in PresS, published online ahead of print February 27, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00348.2001
Submitted on August 6, 2001
Accepted on February 19, 2002

Intestinal preconditioning prevents systemic inflammatory response in hemorrhagic shock. Role of heme-oxygenase-11

Fabienne Tamion1*, Vincent Richard1, Yann Lacoume1, and Christian Thuillez1

1 Department of Pharmacology, INSERM E9920, Rouen, France

* To whom correspondence should be addressed. E-mail: Fabienne.Tamion{at}chu-rouen.fr.

Intestinal ischemia-reperfusion has been implicated in the systemic inflammatory response and distant organ injury in hemorrhagic shock, but the exact role of the intestine has never been demonstrated directly. Preconditioning with brief periods of intermittent ischemia is a known potent anti-ischemic intervention, and thus can be used as a tool to assess the role of local intestinal ischemia-reperfusion injury in systemic inflammatory response. Thus, rats were first subjected to sham surgery or intestinal preconditioning with 4 cycles of 1 min ischemia and 10 min of reperfusion 24 hours before hemorrhagic shock followed by resuscitation. PC reduced fluid requirements, lung edema, lactate and TNF{alpha} production, and these effects were abolished by the HO-1 inhibitor Sn-PP. PC induced a more than 5 fold in intestinal HO-1 expression. These results suggest that intestinal ischemia-reperfusion is a major trigger for inflammatory response and distant organ injury in non septic shock. HO-1 appears to play an important role in the protective effect of intestinal preconditioning.




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