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Am J Physiol Gastrointest Liver Physiol (January 22, 2003). doi:10.1152/ajpgi.00355.2002
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Submitted on August 22, 2002
Accepted on January 21, 2003

Double stranded RNA activates a p38 Mitogen Activated Protein Kinase dependent Cell Survival Program in Biliary Epithelia

Laura Tadlock1, Yoko Yamagiwa1, Carla Marienfeld1, and Tushar Patel1*

1 Scott and White Clinic, Texas A&M University System Health Science Center, College of Medicine, Temple, Texas, USA

* To whom correspondence should be addressed. E-mail: tpatel{at}medicine.tamu.edu.

Double stranded RNA (dsRNA) is produced during replicative viral infection or genotoxic stress. Thus, knowledge of the cellular response to dsRNA is necessary to understand the effects of DNA damage or viral infection in biliary epithelia. We assessed the effect of dsRNA on biliary epithelial cell proliferation and apoptosis, and the role of the stress-activated p38 MAPK signaling pathway in these responses. dsRNA did not induce apoptosis or proliferation in Mz-ChA-1 human malignant cholangiocytes, but decreased cytotoxicity induced by camptothecin or tumor necrosis factor related apoptosis inducing ligand and decreased activity of caspases 3, 8, and 9. Furthermore, dsRNA increased p38 MAPK and JNK kinase active site phosphorylation, but had no effect on either MEK 1/2 or PKR phosphorylation. Inhibition of p38 MAPK with SB203580 increased basal caspase activity. Thus dsRNA stimulates a p38 MAPK dependent cell-survival pathway in biliary epithelial cells that may modulate the response of the biliary epithelia to dsRNA produced during genotoxic injury or virus infection.




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