AJP - GI Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol (April 10, 2002). doi:10.1152/ajpgi.00359.2001
This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
283/2/G384    most recent
00359.2001v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Law, N.-M.
Right arrow Articles by Zinsmeister, A. R
Right arrow Search for Related Content
PubMed
Right arrow Articles by Law, N.-M.
Right arrow Articles by Zinsmeister, A. R

Articles in PresS, published online ahead of print April 10, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00359.2001
Submitted on August 15, 2001
Accepted on April 1, 2002

Rectal and Colonic Distention Elicit Viscero-visceral Reflexes in Humans

Ngai-Moh Law1, Adil E Bharucha1*, and Alan R Zinsmeister2

1 Gastroenterology Research Unit, Mayo Clinic, Rochester, MN, USA
2 Section of Biostatistics, Mayo Clinic, Rochester, MN, USA

* To whom correspondence should be addressed. E-mail: bharucha.adil{at}mayo.edu.

Colonic transit is slowed in patients with disordered rectal evacuation, but the mechanism of this phenomenon is unclear. Our objective was to investigate rectocolonic inhibitory reflexes in humans to provide potential insight into patients with obstructed defecation. In 30 healthy subjects, a barostat-manometric assembly recorded colonic tone and phasic activity in the descending colon during rectal distention, and, conversely, rectal tone during colonic distention. Phasic distentions were 8, 16 and 32 mm Hg above balloon operating pressure and staircase inflations comprised balloon inflation, then deflation in 2 mm Hg increments at 30 second intervals from 0 to 36 mm Hg). Colonic balloon volumes increased to a similar extent during phasic rectal distentions 8, 16 and 32 mm Hg above operating pressure, reflecting reduced colonic tone; balloon volumes also increased and phasic pressure activity decreased during staircase rectal distentions. In contrast, rectal balloon volume declined, reflecting increased tone, during phasic and staircase colonic distentions. Thus, rectal distention inhibited colonic motor activity, indicative of a viscero-visceral inhibitory reflex.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Ng, M. Danta, J. Kellow, C.-A. Badcock, R. Hansen, and A. Malcolm
Attenuation of the colorectal tonic reflex in female patients with irritable bowel syndrome
Am J Physiol Gastrointest Liver Physiol, September 1, 2005; 289(3): G489 - G494.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Liu, L. Wang, and J. D. Z. Chen
Cross-talk along gastrointestinal tract during electrical stimulation: effects and mechanisms of gastric/colonic stimulation on rectal tone in dogs
Am J Physiol Gastrointest Liver Physiol, June 1, 2005; 288(6): G1195 - G1198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
C. Ng, M. Danta, G. Prott, C.-A. Badcock, J. Kellow, and A. Malcolm
Modulatory influences on antegrade and retrograde tonic reflexes in the colon and rectum
Am J Physiol Gastrointest Liver Physiol, November 1, 2004; 287(5): G962 - G966.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH
Visit Other APS Journals Online
Copyright © 1979 by the American Physiological Society.