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Am J Physiol Gastrointest Liver Physiol (October 30, 2002). doi:10.1152/ajpgi.00375.2002
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Articles in PresS, published online ahead of print October 30, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00375.2002
Submitted on August 30, 2002
Accepted on October 12, 2002

Effects of a high-fat diet on gut motility, appetite and plasma hormone responses to duodenal lipid in healthy men

Kathryn A. Boyd1, Deirdre G. O'Donovan1, Selena Doran1, Judith Wishart1, Ian M. Chapman1, Michael Horowitz1, and Christine Feinle1*

1 University of Adelaide Department of Medicine, Royal Adelaide Hospital, Adelaide, South Australia, Australia

* To whom correspondence should be addressed. E-mail: christine.feinle{at}adelaide.edu.au.

There is evidence that gastrointestinal function adapts in response to a high-fat diet. This study investigated the hypothesis that a high-fat diet modifies the acute effects of duodenal lipid on appetite, antropyloroduodenal pressures, plasma cholecystokinin (CCK) and plasma glucagon-like peptide-1 (GLP-1) levels in humans. 12 healthy men were studied twice in randomised, cross-over fashion. The effects of a 90 min duodenal lipid infusion (6.3 kJ/min) on the above parameters were assessed, immediately following 14-day periods on either a high-fat or a low-fat diet. Following the high-fat diet, pyloric tonic and phasic pressures were attenuated, and the number of antropyloroduodenal pressure wave sequences was increased, when compared with the low-fat diet. Plasma CCK and GLP-1 levels did not differ between the two diets. Hunger was greater during the lipid infusion following the high-fat diet, but there was no difference in food intake. Therefore, exposure to a high-fat diet for 14 days attenuates the effects of duodenal lipid on antropyloroduodenal pressures and hunger, without affecting food intake or plasma hormone levels.




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