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Am J Physiol Gastrointest Liver Physiol (August 24, 2006). doi:10.1152/ajpgi.00382.2006
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Submitted on August 17, 2006
Accepted on August 18, 2006

Role of trefoil peptides and IL-6 cytokine family signaling in gastric homeostasis

Andrew S. Giraud1*, Cameron Jackson2, Trevelyan R Menheniott1, and Louise Judd1

1 Department of Medicine, University of Melbourne at Western Hospital, Footscray, Australia
2 Department of Medicine, University of Melbourne at Western Hospital, Footscray, Australia; Medicine, University of Melbourne, Footscray, Victoria, Australia

* To whom correspondence should be addressed. E-mail: asgiraud{at}unimelb.edu.au.

Gastric trefoil peptides mediate mucosal repair by stimulating cell migration, inhibiting apoptosis and inflammation, and likely augmenting the barrier function of mucus. One of these, tff1, is a gastric-specific tumor suppressor gene, which when repressed is associated with gastric cancer progression. IL-6 family cytokines play an important role in maintaining gastric homeostasis, by regulating tff1 and other mediators of mucosal proliferation, inflammation, angiogenesis and apoptosis. In this review the signaling cascades downstream of the common IL-6 cytokine family co-receptor gp130 which contribute to control of this homeostasis are described, as are the pathological outcomes of imbalancing these pathways.




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