| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Surgery, University of Alabama at Birmingham, Birmingham , Alabama, United States
2 Surgery, University of Alabama at Birmingham, Birmingham, Alabama, United States
* To whom correspondence should be addressed. E-mail: Irshad.Chaudry{at}ccc.uab.edu.
Although androstenediol (Adiol, DHEA metabolite) has protective effects following trauma-hemorrhage (T-H), it remains unknown whether administration of Adiol has any salutary effects on inflammatory response and outcome following a combined insult of T-H and sepsis. Male rats underwent T-H shock (MBP 40mmHg for 90 min) followed by resuscitation. Adiol (1 mg/kg BW) or vehicle was administered at the end of resuscitation. Sepsis was induced by cecal ligation and puncture (CLP) at 20 hrs after T-H or sham operation. Five hrs after CLP, plasma and tissue samples were analyzed for cytokines (IL-6 and IL-10), MPO, neutrophil chemotactic factor (CINC-3) and liver injury (ALT, LDH). In another group of rats, the gangrenous cecum was removed at 10 hrs after CLP, the cavity irrigated with warm saline, closed in layers and mortality recorded over 10 days. T-H followed by CLP produced a significant elevation in plasma IL-6 and IL-10 levels, enhanced neutrophil cell activation and resulted in liver injury. Adiol administration prevented the increase in cytokine production, neutrophil cell activation and attenuated liver injury. Moreover, rats subjected to the combined insult receiving vehicle or Adiol had a 50% and 6% mortality, respectively. Since Adiol administration suppresses proinflammatory cytokines, reduces liver damage and decreases mortality after the combined insult of T-H and sepsis, this agent appears to be a novel adjunct to fluid resuscitation for decreasing T-H-induced septic complications and mortality.
This article has been cited by other articles:
|
|
 |
|
  T. A. Markel, P. R. Crisostomo, M. Wang, Y. Wang, T. Lahm, N. M. Novotny, J. Tan, and D. R. Meldrum TNFR1 signaling resistance associated with female stem cell cytokine production is independent of TNFR2-mediated pathways Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2008; 295(4): R1124 - R1130. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Markel, M. Wang, P. R. Crisostomo, M. C. Manukyan, J. A. Poynter, and D. R. Meldrum Neonatal stem cells exhibit specific characteristics in function, proliferation, and cellular signaling that distinguish them from their adult counterparts Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2008; 294(5): R1491 - R1497. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sperry and J. P. Minei Gender dimorphism following injury: making the connection from bench to bedside J. Leukoc. Biol., March 1, 2008; 83(3): 499 - 506. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. Markel, P. R. Crisostomo, M. Wang, C. M. Herring, and D. R. Meldrum Activation of individual tumor necrosis factor receptors differentially affects stem cell growth factor and cytokine production Am J Physiol Gastrointest Liver Physiol, October 1, 2007; 293(4): G657 - G662. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Xiao, C. E. Inal, V. I. Parekh, C.-M. Chang, and M. H. Whitnall 5-Androstenediol Promotes Survival of {gamma}-Irradiated Human Hematopoietic Progenitors through Induction of Nuclear Factor-{kappa}B Activation and Granulocyte Colony-Stimulating Factor Expression Mol. Pharmacol., August 1, 2007; 72(2): 370 - 379. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. Markel, P. R. Crisostomo, M. Wang, C. M. Herring, T. Lahm, K. K. Meldrum, K. D. Lillemoe, F. J. Rescorla, and D. R. Meldrum Iron chelation acutely stimulates fetal human intestinal cell production of IL-6 and VEGF while decreasing HGF: the roles of p38, ERK, and JNK MAPK signaling Am J Physiol Gastrointest Liver Physiol, April 1, 2007; 292(4): G958 - G963. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH |
| Visit Other APS Journals Online |
