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Am J Physiol Gastrointest Liver Physiol (May 10, 2002). doi:10.1152/ajpgi.00415.2001
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Articles in PresS, published online ahead of print May 10, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00415.2001
Submitted on September 27, 2001
Accepted on May 1, 2002

Multipotential stem cells in adult mouse gastric epithelium

Matthew Bjerknes1* and Hazel Cheng1

1 Department of Anatomy and Cell Biology, University of Toronto, Toronto, Ontario, Canada

* To whom correspondence should be addressed. E-mail: matthew.bjerknes{at}utoronto.ca.

Previous studies of chimeric animals demonstrate that multipotential stem cells play a role in the development of the gastric epithelium, however despite much effort it is not clear whether they persist into adulthood. Here, chemical mutagenesis was used to label random epithelial cells by loss of transgene function in adult hemizygous ROSA26 mice, a mouse strain expressing the transgene lacZ in all tissues. Many clones derived from such cells contained all the major epithelial cell types, thereby demonstrating existence of functional multipotential stem cells in adult mouse gastric epithelium. We also observed clones containing only a single mature cell type indicating the presence of long-lived committed progenitors in the gastric epithelium. Similar results were obtained in duodenum and colon showing that this mouse model is suitable for lineage tracing in all regions of the gastrointestinal tract, and likely useful for cell lineage studies in other adult renewing tissues.




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