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Articles in PresS, published online ahead of print February 20, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00422.2001
Submitted on October 3, 2001
Accepted on February 5, 2002
1 Department of Gastroenterology, University of Basel, Basel, Switzerland
2 Institute of Pathology, University of Basel, Basel, Switzerland
3 Experimental Immunology, University of Basel, Basel, Switzerland
4 Department of Gastroenterology, University of Basel, Basel, Switzerland; Operative Unit of Pathology, Oncologic Regional Hospital, Rionero in Vulture, Italy
* To whom correspondence should be addressed. E-mail: falehmann{at}datacomm.ch.
TNF-
and IFN-
are important for the pathogenesis of H. pylori-associated gastritis and peptic ulcer disease. Gastric biopsies from Helicobacter pylori-positive and negative patients were used to examine the in situ correlation of TNF- and IFN- with epithelial cells apoptosis, bacterial load and histological parameters of gastritis. From the same patients, we isolated H. pylori-specific T cell lines and clones and examined their ex vivo release of proinflammatory cytokines.
We found a highly significant correlation of TNF- and IFN- production with activity and grade of gastritis (p<0.01), H. pylori density (p=0.01), epithelial cells apoptosis (p<0.001) and Fas / Fas ligand expression (p<0.001). T cell lines and clones were all TCR ß+ and showed Th1 functional phenotype.
Using serial histological sections this study shows for the first time the in situ correlation of TNF- and IFN- with epithelial cells apoptosis, bacterial load and histological severity of disease and emphasizes the role of these cytokines in the pathophysiology of Helicobacter-associated disease.
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