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Am J Physiol Gastrointest Liver Physiol (March 13, 2003). doi:10.1152/ajpgi.00449.2002
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Submitted on October 21, 2002
Accepted on March 11, 2003

Curcumin attenuates DNB-induced murine colitis

Baljinder S. Salh1*, Kiran Assi1, Valerie Templeman2, Kuljit Parhar1, David Owen1, Antonio Gomez-Munoz3, and Kevan Jacobson2

1 The Jack Bell Research Centre, Vancouver, BC, Canada
2 Department of Pediatric Gastroenterology, Children and Women's Hospital, Vancouver, BC, Canada
3 Department of Biochemistry and Molecular Biology, Faculty of Science, University of the Basque Country, Bilbao, Spain

* To whom correspondence should be addressed. E-mail: bsalh{at}interchange.ubc.ca.

Numerous therapies used for inflammatory bowel disease (IBD) target the transcription factor NF{kappa}B, which is involved in the production of cytokines and chemokines integral for inflammation. Here we show that curcumin, a component of the spice turmeric, is able to attenuate colitis in the DNB-induced murine model of colitis. When given prior to the induction of colitis it reduced macroscopic damage scores and NF{kappa}B activation. This was accompanied by a reduction in myeloperoxidase activity, and using semi-quantitative RT-PCR, an attenuation of the DNB-induced message for interleukin 1{beta} was detected. Western blotting analysis revealed that there was a reproducible DNB-induced activation of p38 MAPK detected in intestinal lysates, using a phosphospecific antibody. This signal was significantly attenuated by curcumin. Furthermore, we show that the immunohistochemical signal is dramatically attenuated at the level of the mucosa by curcumin. We conclude that the widely used food additive curcumin is able to attenuate experimental colitis, through a mechanism correlated with the inhibition of the activation of NF{kappa}B, and effects a reduction in the activity of p38 MAPK. We propose that this agent may have therapeutic implications for human IBD.




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