Submitted on October 23, 2002
Accepted on December 18, 2002
MOTILIN EFFECTS ON THE PROXIMAL STOMACH IN PATIENTS WITH FUNCTIONAL DYSPEPSIA AND HEALTHY VOLUNTEERS
Ingrid MC Kamerling1*, Aernout D. van Haarst1, Jacobus Burggraaf1, Rik C. Schoemaker1, Izak Biemond2, Hartmut Heinzerling3, Richard Jones3, Adam F. Cohen1, and Ad AM Masclee2
1 Centre for Human Drug Research, Leiden, The Netherlands
2 Department of Gastroenterology, Leiden University Medical Center, Leiden, The Netherlands
3 Johnson & Johnson Pharmaceutical Research and Development, High Wycombe, United Kingdom
* To whom correspondence should be addressed. E-mail: ikamerli{at}chdr.nl.
Objectives:
This study investigates motilin effects on the proximal stomach in patients with functional dyspepsia (FD) and healthy volunteers.
Methods:
Eight healthy volunteers and 12 patients with FD were infused with synthetic motilin or placebo. Proximal gastric volume was measured with a barostat at constant pressure and during isobaric distensions. Abdominal symptoms were scored by visual analogue scales. Plasma motilin concentrations were measured by radioimmunoassay.
Results:
Motilin concentrations and baseline gastric volumes were similar for patients and healthy volunteers. Motilin, compared to placebo, reduced gastric volume by 112 mL (CI95%: 29, 195) in patients and by 96 mL (CI95%: -7, 200) in healthy volunteers. In patients, motilin decreased compliance by 76 mL/mmHg (CI95%: 9, 143) compared to placebo, which was similar in volunteers (66 mL/mmHg (CI95%: 11, 120)). Patients were more nauseous during motilin compared to placebo (p=0.04), whereas healthy volunteers did not experience nausea.
Conclusion
In fasted condition, FD patients have a similar proximal gastric motor response to motilin as healthy volunteers, but experience an exaggerated sensation of nausea.
