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Articles in PresS, published online ahead of print January 30, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00466.2001
Submitted on November 1, 2001
Accepted on January 29, 2002
B/I-B pathway during Ischemia-Reperfusion Injury of the Rat Liver
1 Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
* To whom correspondence should be addressed. E-mail: mai{at}kuhp.kyoto-u.ac.jp.
Hepatic ischemia-reperfusion (I/R) injury continues to be a fatal complication after liver surgery. Heat shock (HS) preconditioning is an effective strategy for protecting the liver from I/R injury, but its exact mechanism is still unclear. Since the activation of nuclear factor-B (NF-B) is an important event in the hepatic I/R-induced inflammatory response, the effect of HS preconditioning on the pathway for NF-B activation was investigated. In the control group, NF-B was activated 60 minutes after reperfusion, but this activation was suppressed in the HS group. Messenger RNA expressions of proinflammatory mediators during reperfusion were also reduced with HS preconditioning. Concomitant with NF-B activation, I-B proteins were degraded in the control group, but this degradation was suppressed in the HS group. This study shows that HS preconditioning protected the liver from I/R injury by suppressing the activation of NF-B and the subsequent expression of proinflammatory mediators through the stabilization of I-B proteins.
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