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Am J Physiol Gastrointest Liver Physiol (March 20, 2002). doi:10.1152/ajpgi.00475.2001
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Articles in PresS, published online ahead of print March 20, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00475.2001
Submitted on November 15, 2001
Accepted on March 5, 2002

Distribution of interstitial cells of Cajal and electrical activity in ganglionic and aganglionic colons of mice

Sean M Ward1*, Michael D Gershon2, Kathleen Keef1, Yulia R Bayguinov1, Cheryl Nelson1, and Kenton M Sanders1

1 Department of Physiology and Cell Biology, University of Nevada School of Medicine, Reno, NV, USA
2 Department of Anatomy and Cell Biology, Columbia University, New York, NY, USA

* To whom correspondence should be addressed. E-mail: sean{at}physio.unr.edu.

An antibody directed against Kit protein was used to investigate the distribution of interstitial cells of Cajal (ICC) within the murine colon. The density of ICCs was greatest in the proximal colon and decreased along its length. The distributions of the different classes of ICC in the aganglionic colons of ls/ls mutants, were found to be similar in age-matched controls. There were marked differences in the electrical activities of the colons from ls/ls mutants compared to controls. In the ls/ls aganglionic colons, the circular muscle was electrically quiescent compared to the spontaneous spiking electrical activity of controls. In ls/ls aganglionic colons, post-junctional neural responses were greatly affected. Inhibitory junction potentials were either absent or excitatory junction potentials that were inhibited by atropine were observed. In conclusion, the distribution of ICCs in the ganglionic and aganglionic regions of the colons from ls/ls mutants appeared similar to that of wild type controls. The electrical activity and neural responses of the circular layer are significantly different in aganglionic segments of ls/ls mutants.




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