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Am J Physiol Gastrointest Liver Physiol (February 12, 2003). doi:10.1152/ajpgi.00477.2002
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Submitted on November 4, 2002
Accepted on February 6, 2003

THE EFFECT OF GASTRIC ELECTRICAL STIMULATION ON CANINE GASTRIC SLOW WAVES

Jinhong Xing1, Frederick Brody2, Michael Rosen2, J.D.Z. Chen3, and Edy Soffer1*

1 Department of Gastroenterology, The Cleveland Clinic, Cleveland, OH, USA
2 Department of General Surgery, The Cleveland Clinic, Cleveland, OH, USA
3 University of Texas Medical Branch, Galveston, Texas, USA

* To whom correspondence should be addressed. E-mail: soffere{at}ccf.org.

This study determined the most efficient parameters of low-frequency/long-pulse gastric electrical stimulation (GES) required to entrain gastric slow waves, and also evaluated the effect of entrainment and high-frequency/short-pulse GES on gastric electrical activity. Nine dogs were fitted with stimulation wires along the greater curvature. Entrainment was observed in 6/7 animals with long-pulse GES at 6cpm, at various combinations of current and pulse width, and was directly related to the energy delivered. Entrainment was observed in 4/7 animals with GES at 12cpm, and the maximal driven frequency was 6cpm. Entrainment did not significantly increase the dominant power of gastric electrical activity. High-frequency short-pulse GES, using pulse trains of 14 Hz, 5 mA and 330 µs with 0.1 s on and 5s off, and pulse trains of 40 Hz, 10 mA, 330 µs with 2 s on 3 s off, did not affect variables of gastric electrical activity. We conclude that acute low-frequency GES, but not high-frequency short-pulse GES can entrain slow waves; the power of slow waves is not affected by either type of stimulation.




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[Abstract] [Full Text] [PDF]


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