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Articles in PresS, published online ahead of print March 6, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00497.2001
Submitted on November 19, 2001
Accepted on February 7, 2002
1 Department of Surgery I, Nara Medical University, Kashihara, Nara, Japan
2 Department of Physiology II, Nara Medical University, Kashihara, Nara, Japan
* To whom correspondence should be addressed. E-mail: mtakaki{at}naramed-u.ac.jp.
The aim of the present study was to analyze the neuromodulation of rectoanal reflex activity by lumbar sympathetic nerves in guinea pigs. The mechanical activities of the rectum were recorded with a balloon connected to a pressure transducer and those of internal anal sphincter (IAS) were recorded with a custom-made strain gauge force-transducer. Gradual and sustained rectal distension evoked the rectoanal reflex causing cholinergic contractions of the rectum and synchronous nitrergic relaxations of the internal anal sphincter (IAS). Section of the lumbar colonic nerves enhanced both rectal contractions and IAS relaxations. Section of the 13th thoracic cord abolished both rectal contractions and IAS relaxations but section of the lumbar colonic nerves restored them. Lumbar sympathectomy and pithing sacral cords greatly diminished these rectal contractions and IAS relaxations, but the intrinsic reflex component remained. L-NG-nitro-L-arginine methyl ester enhanced the intrinsic reflex-mediated contraction of the rectum and abolished reflex-mediated relaxation of the IAS and converted into cholinergic contractions. The present results indicate that the extrinsic lumbar inhibitory outflow causes marked inhibition of the rectoanal reflex via the lumbar colonic nerves.
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