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Am J Physiol Gastrointest Liver Physiol (May 19, 2005). doi:10.1152/ajpgi.00526.2004
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Submitted on November 29, 2004
Accepted on April 4, 2005

NF-{kappa}B activation in Kupffer cells after partial hepatectomy

Liu Yang1, Scott T. Magness1, Ramon Bataller1, Richard A. Rippe1, and David A. Brenner1*

1 Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

* To whom correspondence should be addressed. E-mail: dab2106{at}columbia.edu.

The transcription factor NF-{kappa}B is activated during liver regeneration after partial hepatectomy. However, the physiological role and cellular localization of NF-{kappa}B activation are unresolved. In this study we use an adenoviral vector expressing a mutated form of IêBá to inhibit NF-{kappa}B activity during liver regeneration. Following partial hepatectomy in mice, introduction of Ad5IêB, but not a control virus (Ad5GFP), resulted in increased liver injury and decreased hepatocyte proliferation. Hepatocyte apoptosis was not observed. To investigate the kinetics and cellular localization of NF-{kappa}B-induced transcription during liver regeneration, we generated a transgenic mouse expressing the enhanced green fluorescent protein (EGFP) under the transcriptional control of NF-{kappa}B cis-elements (cis-NF-{kappa}B-EGFP). During liver regeneration, EGFP expression was detected within 12 h and primarily located in Kupffer cells. Our data demonstrate that activation of NF-{kappa}B initially occurs in Kupffer cells following partial hepatectomy in mice.




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