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Articles in PresS, published online ahead of print April 24, 2002
Am J Physiol Gastrointest Liver Physiol, 10.1152/ajpgi.00538.2001
Submitted on December 21, 2001
Accepted on April 17, 2002
1 Deparment of Physiology, University of Liverpool, Liverpool, United Kingdom
2 Division of Gastroenterology Division, University of Massachusetts Medical Center, Worcester, Massachusetts, United Kingdom
* To whom correspondence should be addressed. E-mail: g.j.dockray{at}liverpool.ac.uk.
Recent studies suggest gastrin regulates parietal cell maturation. We asked whether it also regulates parietal cell life span, and migration along the gland. Dividing cells were labelled with 5-bromo-2-deoxyuridine (BrdU) and parietal cells were identified by staining with Dolichos biflorus lectin (DBL). Cells positive for DBL and BrdU were reliably identified 10 - 30 days after BrdU injection in mice in which the gastrin gene had been deleted by homologous recombination (Gas-KO) and wild type (C57Bl/6) mice. The time course of labelling was similar in the two groups. The distribution of BrdU-labelled parietal cells in w/t mice was consistent with migration to the base of the gland, but in Gas-KO mice a relatively high proportion of BrdU-labelled cells was found more superficially, both 20 and 30 days after BrdU injection. Conversely, in transgenic mice over-expressing gastrin, BrdU-labelled parietal cells accounted for a higher proportion of the labelled pool in the base of the gland 10-days after BrdU. Gastrin therefore stimulates movement of parietal cells along the gland axis, but does not influence their life span.
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