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Am J Physiol Gastrointest Liver Physiol (December 28, 2006). doi:10.1152/ajpgi.00566.2006
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Submitted on December 12, 2006
Accepted on December 18, 2006

Emerging Role of Lipid Droplet Protein ADFP in Health and Disease

Benny Hung-Junn Chang1 and Lawrence Chan1*

1 Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States

* To whom correspondence should be addressed. E-mail: lchan{at}bcm.edu.

ADFP is the major lipid droplet protein present in all cells that accumulate lipids either normally or abnormally. Although discovered about fifteen years ago, it was only in the last few years that we began to have a working knowledge of its possible role in lipid droplet homeostasis at the whole organism level. In this perspective, we will concentrate on the potential function of ADFP in various tissues. Space limitation has precluded a complete cataloging of all publications on the topic. We will instead highlight some of the salient developments in the last few years.




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