AJP - GI AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 269: G467-G475, 1995;
0193-1857/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Anderson, J. M.
Right arrow Articles by Van Itallie, C. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Anderson, J. M.
Right arrow Articles by Van Itallie, C. M.

AJP - Gastrointestinal and Liver Physiology, Vol 269, Issue 4 467-G475, Copyright © 1995 by American Physiological Society

ARTICLES

Tight junctions and the molecular basis for regulation of paracellular permeability

J. M. Anderson and C. M. Van Itallie
Division of Digestive Diseases, Yale School of Medicine, New Haven, Connecticut 06520-8019, USA.

Tight junctions create a regulated paracellular barrier to the movement of water, solutes, and immune cells between both epithelial and endothelial cells. Recent progress has been made in identifying the proteins that create this barrier. The transmembrane protein occludin is an excellent candidate for the sealing protein and is bound on the cytoplasmic membrane surface to the proteins ZO-1 and ZO-2. Functions for ZO-1 and ZO-2 are suggested by their invertebrate homologues, one of which is a tumor suppressor and another is required in epidermal growth factor receptor signaling. Multiple cellular signaling pathways affect assembly and sealing of junctions. Dynamic regulation of perijunctional actin has emerged as a unifying hypothesis for controlling paracellular permeability. Understanding and manipulating permeability will require a more detailed molecular characterization of tight junction proteins and in particular a characterization of how cell signaling regulates their attachment to the perijunctional cytoskeleton.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. Mazzon, C. Crisafulli, M. Galuppo, and S. Cuzzocrea
Role of peroxisome proliferator-activated receptor-{alpha} in ileum tight junction alteration in mouse model of restraint stress
Am J Physiol Gastrointest Liver Physiol, September 1, 2009; 297(3): G488 - G505.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
G. Damera, H. Zhao, M. Wang, M. Smith, C. Kirby, W. F. Jester, J. A. Lawson, and R. A. Panettieri Jr.
Ozone modulates IL-6 secretion in human airway epithelial and smooth muscle cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2009; 296(4): L674 - L683.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
N. Li and J. Neu
Glutamine Deprivation Alters Intestinal Tight Junctions via a PI3-K/Akt Mediated Pathway in Caco-2 Cells
J. Nutr., April 1, 2009; 139(4): 710 - 714.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
E. Mazzon and S. Cuzzocrea
Role of TNF-{alpha} in ileum tight junction alteration in mouse model of restraint stress
Am J Physiol Gastrointest Liver Physiol, May 1, 2008; 294(5): G1268 - G1280.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Seth, F. Yan, D. B. Polk, and R. K. Rao
Probiotics ameliorate the hydrogen peroxide-induced epithelial barrier disruption by a PKC- and MAP kinase-dependent mechanism
Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G1060 - G1069.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
V. S. Subramanian, J. S. Marchant, D. Ye, T. Y. Ma, and H. M. Said
Tight junction targeting and intracellular trafficking of occludin in polarized epithelial cells
Am J Physiol Cell Physiol, November 1, 2007; 293(5): C1717 - C1726.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
P. Sheth, N. Delos Santos, A. Seth, N. F. LaRusso, and R. K. Rao
Lipopolysaccharide disrupts tight junctions in cholangiocyte monolayers by a c-Src-, TLR4-, and LBP-dependent mechanism
Am J Physiol Gastrointest Liver Physiol, July 1, 2007; 293(1): G308 - G318.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
L. Eiselein, D. W. Wilson, M. W. Lame, and J. C. Rutledge
Lipolysis products from triglyceride-rich lipoproteins increase endothelial permeability, perturb zonula occludens-1 and F-actin, and induce apoptosis
Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2745 - H2753.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
A. T. Blikslager, A. J. Moeser, J. L. Gookin, S. L. Jones, and J. Odle
Restoration of Barrier Function in Injured Intestinal Mucosa
Physiol Rev, April 1, 2007; 87(2): 545 - 564.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. J. Moeser, P. K. Nighot, K. J. Engelke, R. Ueno, and A. T. Blikslager
Recovery of mucosal barrier function in ischemic porcine ileum and colon is stimulated by a novel agonist of the ClC-2 chloride channel, lubiprostone
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G647 - G656.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. A. Boivin, D. Ye, J. C. Kennedy, R. Al-Sadi, C. Shepela, and T. Y. Ma
Mechanism of glucocorticoid regulation of the intestinal tight junction barrier
Am J Physiol Gastrointest Liver Physiol, February 1, 2007; 292(2): G590 - G598.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Chakraborty, H. Brooks, P. Zhang, W. Smith, M. R. McReynolds, J. B. Hoying, R. Bick, L. Truong, B. Poindexter, H. Lan, et al.
Stanniocalcin-1 regulates endothelial gene expression and modulates transendothelial migration of leukocytes
Am J Physiol Renal Physiol, February 1, 2007; 292(2): F895 - F904.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. Dokladny, P. L. Moseley, and T. Y. Ma
Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability
Am J Physiol Gastrointest Liver Physiol, February 1, 2006; 290(2): G204 - G212.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. B. N. Lee, E. Huang, and H. J. Ward
Tight junction biology and kidney dysfunction
Am J Physiol Renal Physiol, January 1, 2006; 290(1): F20 - F34.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. Basuroy, P. Sheth, C. M. Mansbach, and R. K. Rao
Acetaldehyde disrupts tight junctions and adherens junctions in human colonic mucosa: protection by EGF and L-glutamine
Am J Physiol Gastrointest Liver Physiol, August 1, 2005; 289(2): G367 - G375.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. P. Chen, B. Zhou, B. C. Willis, A. J. Sandoval, J. M. Liebler, K.-J. Kim, D. K. Ann, E. D. Crandall, and Z. Borok
Effects of transdifferentiation and EGF on claudin isoform expression in alveolar epithelial cells
J Appl Physiol, January 1, 2005; 98(1): 322 - 328.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Seth, S. Basuroy, P. Sheth, and R. K. Rao
L-Glutamine ameliorates acetaldehyde-induced increase in paracellular permeability in Caco-2 cell monolayer
Am J Physiol Gastrointest Liver Physiol, September 1, 2004; 287(3): G510 - G517.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
R. K. Rao, A. Seth, and P. Sheth
Recent Advances in Alcoholic Liver Disease I. Role of intestinal permeability and endotoxemia in alcoholic liver disease
Am J Physiol Gastrointest Liver Physiol, June 1, 2004; 286(6): G881 - G884.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J.-M. Otte and D. K. Podolsky
Functional modulation of enterocytes by gram-positive and gram-negative microorganisms
Am J Physiol Gastrointest Liver Physiol, April 1, 2004; 286(4): G613 - G626.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. Eisen, D. R. Ratcliffe, and G. K. Ojakian
Modulation of epithelial tubule formation by Rho kinase
Am J Physiol Cell Physiol, April 1, 2004; 286(4): C857 - C866.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Y. Ma, G. K. Iwamoto, N. T. Hoa, V. Akotia, A. Pedram, M. A. Boivin, and H. M. Said
TNF-{alpha}-induced increase in intestinal epithelial tight junction permeability requires NF-{kappa}B activation
Am J Physiol Gastrointest Liver Physiol, March 1, 2004; 286(3): G367 - G376.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
X. Han, M. P. Fink, T. Uchiyama, R. Yang, and R. L. Delude
Increased iNOS activity is essential for pulmonary epithelial tight junction dysfunction in endotoxemic mice
Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L259 - L267.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. K. Rajasekaran and S. A. Rajasekaran
Role of Na-K-ATPase in the assembly of tight junctions
Am J Physiol Renal Physiol, September 1, 2003; 285(3): F388 - F396.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
O. Nylander, L. Pihl, and M. Perry
Hypotonicity-induced increases in duodenal mucosal permeability facilitates adjustment of luminal osmolality
Am J Physiol Gastrointest Liver Physiol, July 7, 2003; 285(2): G360 - G370.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Gopalakrishnan, M. A. Hallett, S. J. Atkinson, and James. A. Marrs
Differential regulation of junctional complex assembly in renal epithelial cell lines
Am J Physiol Cell Physiol, July 1, 2003; 285(1): C102 - C111.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. A. Rajasekaran, J. Hu, J. Gopal, R. Gallemore, S. Ryazantsev, D. Bok, and A. K. Rajasekaran
Na,K-ATPase inhibition alters tight junction structure and permeability in human retinal pigment epithelial cells
Am J Physiol Cell Physiol, June 1, 2003; 284(6): C1497 - C1507.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
T. Yamada, A. Inui, N. Hayashi, M. Fujimura, and M. Fujimiya
Serotonin stimulates endotoxin translocation via 5-HT3 receptors in the rat ileum
Am J Physiol Gastrointest Liver Physiol, May 1, 2003; 284(5): G782 - G788.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
H. Sasaki, C. Matsui, K. Furuse, Y. Mimori-Kiyosue, M. Furuse, and S. Tsukita
Dynamic behavior of paired claudin strands within apposing plasma membranes
PNAS, April 1, 2003; 100(7): 3971 - 3976.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. S. Liu, M. W. Musch, K. Sugi, M. M. Walsh-Reitz, M. J. Ropeleski, B. A. Hendrickson, C. Pothoulakis, J. T. Lamont, and E. B. Chang
Protective role of HSP72 against Clostridium difficile toxin A-induced intestinal epithelial cell dysfunction
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C1073 - C1082.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
W.-Y. Lui, D. Mruk, W. M Lee, and C. Y. Cheng
Sertoli Cell Tight Junction Dynamics: Their Regulation During Spermatogenesis
Biol Reprod, April 1, 2003; 68(4): 1087 - 1097.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. Basuroy, P. Sheth, D. Kuppuswamy, S. Balasubramanian, R. M. Ray, and R. K. Rao
Expression of Kinase-inactive c-Src Delays Oxidative Stress-induced Disassembly and Accelerates Calcium-mediated Reassembly of Tight Junctions in the Caco-2 Cell Monolayer
J. Biol. Chem., March 28, 2003; 278(14): 11916 - 11924.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
F. Tafazoli, K.-E. Magnusson, and L. Zheng
Disruption of Epithelial Barrier Integrity by Salmonella enterica Serovar Typhimurium Requires Geranylgeranylated Proteins
Infect. Immun., February 1, 2003; 71(2): 872 - 881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Respir. Cell Mol. Bio.Home page
S. M. Evans, D. I. Blyth, T. Wong, S. Sanjar, and M. R. West
Decreased Distribution of Lung Epithelial Junction Proteins after Intratracheal Antigen or Lipopolysaccharide Challenge: Correlation with Neutrophil Influx and Levels of BALF sE-Cadherin
Am. J. Respir. Cell Mol. Biol., October 1, 2002; 27(4): 446 - 454.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. D. Ward, R. R. Klein, M. D. Troutman, S. Desai, and D. R. Thakker
Phospholipase C-gamma Modulates Epithelial Tight Junction Permeability through Hyperphosphorylation of Tight Junction Proteins
J. Biol. Chem., September 13, 2002; 277(38): 35760 - 35765.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Quigley and M. Baum
Developmental changes in rabbit proximal straight tubule paracellular permeability
Am J Physiol Renal Physiol, September 1, 2002; 283(3): F525 - F531.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. Ludwig, R. Ossig, S. Graessel, M. Wilhelmi, H. Oberleithner, and S. W. Schneider
The electrical resistance breakdown assay determines the role of proteinases in tumor cell invasion
Am J Physiol Renal Physiol, August 1, 2002; 283(2): F319 - F327.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. C. Chin, D. A. Teoh, K. G.-E. Scott, J. B. Meddings, W. K. Macnaughton, and A. G. Buret
Strain-Dependent Induction of Enterocyte Apoptosis by Giardia lamblia Disrupts Epithelial Barrier Function in a Caspase-3-Dependent Manner
Infect. Immun., July 1, 2002; 70(7): 3673 - 3680.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
Y. Kiuchi-Saishin, S. Gotoh, M. Furuse, A. Takasuga, Y. Tano, and S. Tsukita
Differential Expression Patterns of Claudins, Tight Junction Membrane Proteins, in Mouse Nephron Segments
J. Am. Soc. Nephrol., April 1, 2002; 13(4): 875 - 886.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Furuse, M. Hata, K. Furuse, Y. Yoshida, A. Haratake, Y. Sugitani, T. Noda, A. Kubo, and S. Tsukita
Claudin-based tight junctions are crucial for the mammalian epidermal barrier: a lesson from claudin-1-deficient mice
J. Cell Biol., March 18, 2002; 156(6): 1099 - 1111.
[Abstract] [Full Text] [PDF]

Home page
 Chem SensesHome page
P. Hussar, N. Tserentsoodol, H. Koyama, M. Yokoo-Sugawara, T. Matsuzaki, S. Takami, and K. Takata
The Glucose Transporter GLUT1 and the Tight Junction Protein Occludin in Nasal Olfactory Mucosa
Chem Senses, January 1, 2002; 27(1): 7 - 11.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Kunzelmann and M. Mall
Electrolyte Transport in the Mammalian Colon: Mechanisms and Implications for Disease
Physiol Rev, January 1, 2002; 82(1): 245 - 289.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
O. Nylander, A. Hallgren, and M. Sababi
COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum
Am J Physiol Gastrointest Liver Physiol, November 1, 2001; 281(5): G1169 - G1178.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y.-H. Wang, F. Li, J. H. Schwartz, P. J. Flint, and S. C. Borkan
c-Src and HSP72 interact in ATP-depleted renal epithelial cells
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1667 - C1675.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. J. Sawyer, S. M. Norvell, S. M. Ponik, and F. M. Pavalko
Regulation of PGE2 and PGI2 release from human umbilical vein endothelial cells by actin cytoskeleton
Am J Physiol Cell Physiol, September 1, 2001; 281(3): C1038 - C1045.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Q. Wang, C. H. Fang, and P.-O. Hasselgren
Intestinal permeability is reduced and IL-10 levels are increased in septic IL-6 knockout mice
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2001; 281(3): R1013 - R1023.
[Abstract] [Full Text] [PDF]

Home page
 JCBHome page
M. Itoh, H. Sasaki, M. Furuse, H. Ozaki, T. Kita, and S. Tsukita
Junctional adhesion molecule (JAM) binds to PAR-3: a possible mechanism for the recruitment of PAR-3 to tight junctions
J. Cell Biol., August 6, 2001; 154(3): 491 - 498.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. J. Watson, M. Rowland, and G. Warhurst
Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers
Am J Physiol Cell Physiol, August 1, 2001; 281(2): C388 - C397.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
H M Roche, A M Terres, I B Black, M J Gibney, and D Kelleher
Fatty acids and epithelial permeability: effect of conjugated linoleic acid in Caco-2 cells
Gut, June 1, 2001; 48(6): 797 - 802.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. J. Atkinson and R. K. Rao
Role of protein tyrosine phosphorylation in acetaldehyde-induced disruption of epithelial tight junctions
Am J Physiol Gastrointest Liver Physiol, June 1, 2001; 280(6): G1280 - G1288.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
M. A. Unmack, P. K. Rangachari, and E. Skadhauge
Effects of Isoprostanes and Prostanoids on Porcine Small Intestine
J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 434 - 441.
[Abstract] [Full Text]

Home page
 Mol. Biol. CellHome page
X. Lou, H. Yano, F. Lee, M. V. Chao, and M. G. Farquhar
GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways
Mol. Biol. Cell, March 1, 2001; 12(3): 615 - 627.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
W. Wang, W. L. Dentler, and R. T. Borchardt
VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly
Am J Physiol Heart Circ Physiol, January 1, 2001; 280(1): H434 - H440.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
M. Saitou, M. Furuse, H. Sasaki, J.-D. Schulzke, M. Fromm, H. Takano, T. Noda, and S. Tsukita
Complex Phenotype of Mice Lacking Occludin, a Component of Tight Junction Strands
Mol. Biol. Cell, December 1, 2000; 11(12): 4131 - 4142.
[Abstract] [Full Text]

Home page
 FASEB J.Home page
A. H. GITTER, K. BENDFELDT, J.-D. SCHULZKE, and M. FROMM
Leaks in the epithelial barrier caused by spontaneous and TNF-{alpha}-induced single-cell apoptosis
FASEB J, September 1, 2000; 14(12): 1749 - 1753.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. M. Wiener, R. F. Hoyt Jr., J. R. Deleonardis, R. R. Clevenger, K. R. Jeffries, K. Nagashima, M. Mandel, J. Owens, M. Eckhaus, R. J. Lutz, et al.
Manometric changes during retrograde biliary infusion in mice
Am J Physiol Gastrointest Liver Physiol, July 1, 2000; 279(1): G49 - G66.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
I. Peiffer, A.-B. Blanc-Potard, M.-F. Bernet-Camard, J. Guignot, A. Barbat, and A. L. Servin
Afa/Dr Diffusely Adhering Escherichia coli C1845 Infection Promotes Selective Injuries in the Junctional Domain of Polarized Human Intestinal Caco-2/TC7 Cells
Infect. Immun., June 1, 2000; 68(6): 3431 - 3442.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
G. Obert, I. Peiffer, and A. L. Servin
Rotavirus-Induced Structural and Functional Alterations in Tight Junctions of Polarized Intestinal Caco-2 Cell Monolayers
J. Virol., May 15, 2000; 74(10): 4645 - 4651.
[Abstract] [Full Text]

Home page
 Mol. Biol. CellHome page
S. W. Ryeom, D. Paul, and D. A. Goodenough
Truncation Mutants of the Tight Junction Protein ZO-1 Disrupt Corneal Epithelial Cell Morphology
Mol. Biol. Cell, May 1, 2000; 11(5): 1687 - 1696.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
D. MACCONI, M. GHILARDI, M. E. BONASSI, E. I. MOHAMED, M. ABBATE, F. COLOMBI, G. REMUZZI, and A. REMUZZI
Effect of Angiotensin-Converting Enzyme Inhibition on Glomerular Basement Membrane Permeability and Distribution of Zonula Occludens-1 in MWF Rats
J. Am. Soc. Nephrol., March 1, 2000; 11(3): 477 - 489.
[Abstract] [Full Text] [PDF]

Home page
 Mol. Biol. CellHome page
Y.-h. Chen, Q. Lu, E. E. Schneeberger, and D. A. Goodenough
Restoration of Tight Junction Structure and Barrier Function by Down-Regulation of the Mitogen-activated Protein Kinase Pathway in Ras-transformed Madin-Darby Canine Kidney Cells
Mol. Biol. Cell, March 1, 2000; 11(3): 849 - 862.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. T. Blikslager, M. C. Roberts, K. M. Young, J. M. Rhoads, and R. A. Argenzio
Genistein augments prostaglandin-induced recovery of barrier function in ischemia-injured porcine ileum
Am J Physiol Gastrointest Liver Physiol, February 1, 2000; 278(2): G207 - G216.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. A. Antonetti, A. J. Barber, L. A. Hollinger, E. B. Wolpert, and T. W. Gardner
Vascular Endothelial Growth Factor Induces Rapid Phosphorylation of Tight Junction Proteins Occludin and Zonula Occluden 1. A POTENTIAL MECHANISM FOR VASCULAR PERMEABILITY IN DIABETIC RETINOPATHY AND TUMORS
J. Biol. Chem., August 13, 1999; 274(33): 23463 - 23467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. L. Underwood, C. G. Murphy, J. Chen, L. Franse-Carman, I. Wood, D. L. Epstein, and J. A. Alvarado
Glucocorticoids regulate transendothelial fluid flow resistance and formation of intercellular junctions
Am J Physiol Cell Physiol, August 1, 1999; 277(2): C330 - C342.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. C. Michel and F. E. Curry
Microvascular Permeability
Physiol Rev, July 1, 1999; 79(3): 703 - 761.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. S. FANNING, L. L. MITIC, and J. M. ANDERSON
Transmembrane Proteins in the Tight Junction Barrier
J. Am. Soc. Nephrol., June 1, 1999; 10(6): 1337 - 1345.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
A. Youakim and M. Ahdieh
Interferon-gamma decreases barrier function in T84 cells by reducing ZO-1 levels and disrupting apical actin
Am J Physiol Gastrointest Liver Physiol, May 1, 1999; 276(5): G1279 - G1288.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
D M McKAY and A W BAIRD
Cytokine regulation of epithelial permeability and ion transport
Gut, February 1, 1999; 44(2): 283 - 289.
[Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Morita, M. Furuse, K. Fujimoto, and S. Tsukita
Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands
PNAS, January 19, 1999; 96(2): 511 - 516.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
C. YEAMAN, K. K. GRINDSTAFF, and W. J. NELSON
New Perspectives on Mechanisms Involved in Generating Epithelial Cell Polarity
Physiol Rev, January 1, 1999; 79(1): 73 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Wu, K.-C. Lim, J. Huang, R. F. Saidi, and C. L. Sears
Bacteroides fragilis enterotoxin cleaves the zonula adherens protein, E-cadherin
PNAS, December 8, 1998; 95(25): 14979 - 14984.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
G. Wang, B. L. Davidson, P. Melchert, V. A. Slepushkin, H. H. G. van Es, M. Bodner, D. J. Jolly, and P. B. McCray Jr.
Influence of Cell Polarity on Retrovirus-Mediated Gene Transfer to Differentiated Human Airway Epithelia
J. Virol., December 1, 1998; 72(12): 9818 - 9826.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
K. B. Hoover, S.-Y. Liao, and P. J. Bryant
Loss of the Tight Junction MAGUK ZO-1 in Breast Cancer : Relationship to Glandular Differentiation and Loss ofHeterozygosity
Am. J. Pathol., December 1, 1998; 153(6): 1767 - 1773.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
A. S. Fanning, B. J. Jameson, L. A. Jesaitis, and J. M. Anderson
The Tight Junction Protein ZO-1 Establishes a Link between the Transmembrane Protein Occludin and the Actin Cytoskeleton
J. Biol. Chem., November 6, 1998; 273(45): 29745 - 29753.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Gopalakrishnan, N. Raman, S. J. Atkinson, and J. A. Marrs
Rho GTPase signaling regulates tight junction assembly and protects tight junctions during ATP depletion
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C798 - C809.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. M. Mullin, J. A. Kampherstein, K. V. Laughlin, C. E. K. Clarkin, R. D. Miller, Z. Szallasi, B. Kachar, A. P. Soler, and D. Rosson
Overexpression of protein kinase C-delta increases tight junction permeability in LLC-PK1 epithelia
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C544 - C554.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
A. M. Terres, J. M. Pajares, A. M. Hopkins, A. Murphy, A. Moran, A. W. Baird, and D. Kelleher
Helicobacter pylori Disrupts Epithelial Barrier Function in a Process Inhibited by Protein Kinase C Activators
Infect. Immun., June 1, 1998; 66(6): 2943 - 2950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
R. H. Adamson, B. Liu, G. N. Fry, L. L. Rubin, and F. E. Curry
Microvascular permeability and number of tight junctions are modulated by cAMP
Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H1885 - H1894.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. M. Fu, R. H. Adamson, and F. E. Curry
Test of a two-pathway model for small-solute exchange across the capillary wall
Am J Physiol Heart Circ Physiol, June 1, 1998; 274(6): H2062 - H2073.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T. M. Clark, T. K. Hayes, and K. W. Beyenbach
Dose-dependent effects of CRF-like diuretic peptide on transcellular and paracellular transport pathways
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F834 - F840.
[Abstract] [Full Text] [PDF]

Home page
 PhysiologyHome page
N. H. Garcia, C. R. Ramsey, and F. G. Knox
Understanding the Role of Paracellular Transport in the Proximal Tubule
Physiology, February 1, 1998; 13(1): 38 - 43.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. V. Chirayath, L. Gajdzik, W. Hulla, J. Graf, H. S. Cross, and M. Peterlik
Vitamin D increases tight-junction conductance and paracellular Ca2+ transport in Caco-2 cell cultures
Am J Physiol Gastrointest Liver Physiol, February 1, 1998; 274(2): G389 - G396.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. M. Denker and S. K. Nigam
Molecular structure and assembly of the tight junction
Am J Physiol Renal Physiol, January 1, 1998; 274(1): F1 - F9.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Matsui, L. G. Johnson, S. H. Randell, and R. C. Boucher
Loss of Binding and Entry of Liposome-DNA Complexes Decreases Transfection Efficiency in Differentiated Airway Epithelial Cells
J. Biol. Chem., January 10, 1997; 272(2): 1117 - 1126.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. J. M. Ceponis, F. Botelho, C. D. Richards, and D. M. McKay
Interleukins 4 and 13 Increase Intestinal Epithelial Permeability by a Phosphatidylinositol 3-Kinase Pathway. LACK OF EVIDENCE FOR STAT 6 INVOLVEMENT
J. Biol. Chem., September 8, 2000; 275(37): 29132 - 29137.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
S. N. Mattagajasingh, S.-C. Huang, J. S. Hartenstein, and E. J. Benz Jr.
Characterization of the Interaction between Protein 4.1R and ZO-2. A POSSIBLE LINK BETWEEN THE TIGHT JUNCTION AND THE ACTIN CYTOSKELETON
J. Biol. Chem., September 22, 2000; 275(39): 30573 - 30585.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. Hirase, S. Kawashima, E. Y. M. Wong, T. Ueyama, Y. Rikitake, S. Tsukita, M. Yokoyama, and J. M. Staddon
Regulation of Tight Junction Permeability and Occludin Phosphorylation by RhoA-p160ROCK-dependent and -independent Mechanisms
J. Biol. Chem., March 23, 2001; 276(13): 10423 - 10431.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
R. Nishiyama, T. Sakaguchi, T. Kinugasa, X. Gu, R. P. MacDermott, D. K. Podolsky, and H.-C. Reinecker
Interleukin-2 Receptor beta Subunit-dependent and -independent Regulation of Intestinal Epithelial Tight Junctions
J. Biol. Chem., September 14, 2001; 276(38): 35571 - 35580.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
Y. Hamazaki, M. Itoh, H. Sasaki, M. Furuse, and S. Tsukita
Multi-PDZ Domain Protein 1 (MUPP1) Is Concentrated at Tight Junctions through Its Possible Interaction with Claudin-1 and Junctional Adhesion Molecule
J. Biol. Chem., January 4, 2002; 277(1): 455 - 461.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online