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Am J Physiol Gastrointest Liver Physiol 282: G624-G633, 2002. First published December 5, 2001; doi:10.1152/ajpgi.00354.2001
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Vol. 282, Issue 4, G624-G633, April 2002

Somatostatin sst2 receptors inhibit peristalsis in the rat and mouse jejunum

Faiza Abdu1, Gareth A. Hicks2, Grant Hennig3, Jeremy P. Allen4, and David Grundy1

1 Department of Biomedical Science, Alfred Denny Building, University of Sheffield, Western Bank, Sheffield S10 2TN; 2 GlaxoSmithKline, Gastrointestinal Department, Neurology CEDD, New Frontiers Science Park, Harlow CM19 5AW; 4 Laboratory of Cognitive and Developmental Neuroscience, The Babraham Institute, Babraham, Cambridge, CB2 4AT, United Kingdom; and 3 Department of Physiology and Cell Biology, College of Medicine, University of Nevada, Reno, Nevada 89557

Somatostatin [somatotropin release-inhibitory factor (SRIF)] has widespread actions throughout the gastrointestinal tract, but the receptor mechanisms involved are not fully characterized. We have examined the effect of selective SRIF-receptor ligands on intestinal peristalsis by studying migrating motor complexes (MMCs) in isolated segments of jejunum from rats, mice, and sst2-receptor knockout mice. MMCs were recorded in 4- to 5-cm segments of jejunum mounted horizontally in vitro. MMCs occurred in rat and mouse jejunum with intervals of 104.4 ± 10 and 131.2 ± 8 s, respectively. SRIF, octreotide, and BIM-23027 increased the interval between MMCs, an effect fully or partially antagonized by the sst2-receptor antagonist Cyanamid154806. A non-sst2 receptor-mediated component was evident in mouse as confirmed by the observation of an inhibitory action of SRIF in sst2 knockout tissue. Blocking nitric oxide generation abolished the response to SRIF in rat but not mouse jejunum. sst2 Receptors mediate inhibition of peristalsis in both rat and mouse jejunum, but a non-sst2 component also exists in the mouse. Nitrergic mechanisms are differentially involved in rat and mouse jejunum.

knockout; migrating motor complex; enteric nervous system; somatotropin release-inhibitory factor


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