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Am J Physiol Gastrointest Liver Physiol 282: G742-G746, 2002. First published January 16, 2002; doi:10.1152/ajpgi.00531.2001
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Vol. 282, Issue 5, G742-G746, May 2002

THEME
Nuclear Receptors
II. Intestinal corticosteroid receptors

Karen E. Sheppard

Baker Medical Research Institute, Melbourne, Victoria 8008, Australia

Two corticosteroid receptors have been cloned; they are the glucocorticoid receptor and the mineralocorticoid receptor. These receptors are members of the steroid/thyroid/retinoid receptor family of nuclear transactivating factors, which are characterized by two highly conserved zinc fingers in the central DNA binding domain, a COOH-terminal domain that encompasses the ligand binding site, and a variable NH2-terminal domain. In addition to these cloned receptors, other corticosteroid receptors have recently been identified in intestine. Steroid binding studies have identified two novel putative corticosteroid receptors in intestinal epithelia, and molecular cloning studies have detected two low-affinity receptors in small intestine that are activated by corticosteroids and induce CYP3A gene expression. This article focuses on the identification of these novel corticosteroid receptors and the potential role they may play in intestinal physiology.

intestine; mineralocorticoid receptor; glucocorticoid receptor


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