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Am J Physiol Gastrointest Liver Physiol 283: G827-G832, 2002. First published May 29, 2002; doi:10.1152/ajpgi.00162.2002
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Vol. 283, Issue 4, G827-G832, October 2002

THEME
Aging and Neural Control of the GI Tract
II. Neural control of the aging gut: can an old dog learn new tricks?

Karen E. Hall

Geriatric Research, Education, and Clinical Center, Ann Arbor Veterans Affairs Healthcare System, Ann Arbor 48105; and Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109

There has been a dramatic increase in funding available for aging research, primarily due to the fact that answers to questions on aging are likely to have a major impact on the well-being and healthy aging of the world's population for decades to come. The incidence of certain gastrointestinal problems, such as dysphagia and constipation, increases dramatically with age. Changes in gastrointestinal neuromuscular function with aging have been demonstrated in both human and animal models of aging. This article focuses on recent advances in our knowledge of the effects of aging on gastrointestinal function, treatment options, and future opportunities for research.

aging myentene; dysphagia; constipation; neuronal dysfunction





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