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evokes
enterocyte apoptosis with parenteral nutrition in mice
Section of Pediatric Surgery, Department of Surgery, University of Michigan Medical School and C. S. Mott Children's Hospital, Ann Arbor, Michigan 48109
Total
parenteral nutrition (TPN) results in an increase in intraepithelial
lymphocyte (IEL)-derived interferon-
(IFN-) expression as well as
an increase in epithelial cell (EC) apoptosis. This study
examined the role that IEL-derived IFN- has in the increase in EC
apoptosis. Mice received either TPN or oral feedings for 7 days. Small bowel EC apoptosis significantly rose in mice
receiving TPN. The administration of TPN also significantly increased
IEL-derived IFN- and Fas ligand (FasL) expression. EC
apoptosis in IFN- knockout (IFNKO) mice that received TPN
was significantly lower than in wild-type TPN mice. Sensitivity of EC
to Fas-mediated apoptosis in IFNKO mice was significantly lower
than in wild-type TPN mice. Apoptosis in Fas-deficient and
FasL-deficient mice that received TPN was significantly lower than in
wild-type mice that received TPN. The TPN-induced increase in IFN-
expression appears to result in an increase in Fas-L expression and EC
sensitivity to Fas, with a resultant increase in EC apoptosis.
This may well be one of the mediators of increased EC apoptosis
observed with TPN administration.
epithelial cells; cytokine; Fas; Fas ligand
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