AJP - GI AJP: Gastrointestinal and Liver Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Gastrointest Liver Physiol 285: G621-G629, 2003. First published May 28, 2003; doi:10.1152/ajpgi.00177.2003
0193-1857/03 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
285/3/G621    most recent
00177.2003v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (42)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, R.
Right arrow Articles by Fink, M. P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, R.
Right arrow Articles by Fink, M. P.

INFLAMMATION/IMMUNITY/MEDIATORS

IL-6 is essential for development of gut barrier dysfunction after hemorrhagic shock and resuscitation in mice

Runkuan Yang,1 Xiaonan Han,1 Takashi Uchiyama,1 Simon K. Watkins,2 Arino Yaguchi,1 Russell L. Delude,1,3 and Mitchell P. Fink1,4

Departments of 1Critical Care Medicine, 3Pathology, and 4Surgery and the 2Center for Biologic Imaging, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260

Submitted 16 April 2003 ; accepted in final form 16 May 2003

We sought to determine the role of IL-6 as a mediator of the alterations in gut barrier function that occur after hemorrhagic shock and resuscitation (HS/R). C57Bl/6 wild-type (WT) and IL-6 knockout (KO) mice on a C57Bl/6 background were subjected to either a sham procedure or HS/R. Organ and tissue samples were obtained 4 h after resuscitation. In WT mice, HS/R significantly increased ileal mucosal permeability to fluorescein isothiocyanate-labeled dextran (average molecular mass, 4 kDa) and bacterial translocation to mesenteric lymph nodes. These alterations in gut barrier function were not observed in IL-6 KO animals. HS/R increased ileal steady-state mRNA levels for IL-6, TNF, and IL-10 in WT but not in IL-6 KO mice. Ileal mucosal expression of the tight junction protein, ZO-1, decreased after HS/R in WT but not IL-6 KO mice. Collectively, these data support the view that expression of IL-6 is essential for the development of gut barrier dysfunction after HS/R.

mesenteric lymph nodes; mucosal permeability; inducible nitric oxide synthase


Address for reprint requests and other correspondence: M. P. Fink, Dept. of Critical Care Medicine, Scaife Hall, 3550 Terrace St., Pittsburgh, PA 15260 (E-mail: finkmp{at}ccm.upmc.edu).




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. A. Clark, H. Gan, A. J. Samocha, A. C. Fox, T. G. Buchman, and C. M. Coopersmith
Enterocyte-specific epidermal growth factor prevents barrier dysfunction and improves mortality in murine peritonitis
Am J Physiol Gastrointest Liver Physiol, September 1, 2009; 297(3): G471 - G479.
[Abstract] [Full Text] [PDF]

Home page
 GutHome page
P D Cani, S Possemiers, T Van de Wiele, Y Guiot, A Everard, O Rottier, L Geurts, D Naslain, A Neyrinck, D M Lambert, et al.
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
Gut, August 1, 2009; 58(8): 1091 - 1103.
[Abstract] [Full Text] [PDF]

Home page
 Arch Intern MedHome page
J. A. Kellum and D. C. Angus
Mortality in Humans With Pneumonia and Sepsis Is Related to an Uncompensated Anti-inflammatory Response to Infection--Reply
Arch Intern Med, July 14, 2008; 168(13): 1469 - 1469.
[Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. Lin, C.-F. Cheng, H.-H. Hou, W.-S. Lian, Y.-C. Chao, Y.-Y. Ciou, B. Djoko, M.-T. Tsai, C.-J. Cheng, and R.-B. Yang
Disruption of Guanylyl Cyclase-G Protects against Acute Renal Injury
J. Am. Soc. Nephrol., February 1, 2008; 19(2): 339 - 348.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
X. Sun, H. Yang, K. Nose, S. Nose, E. Q. Haxhija, H. Koga, Y. Feng, and D. H. Teitelbaum
Decline in intestinal mucosal IL-10 expression and decreased intestinal barrier function in a mouse model of total parenteral nutrition
Am J Physiol Gastrointest Liver Physiol, January 1, 2008; 294(1): G139 - G147.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. G. Raman, P. L. Sappington, R. Yang, R. M. Levy, J. M. Prince, S. Liu, S. K. Watkins, A. M. Schmidt, T. R. Billiar, and M. P. Fink
The role of RAGE in the pathogenesis of intestinal barrier dysfunction after hemorrhagic shock
Am J Physiol Gastrointest Liver Physiol, October 1, 2006; 291(4): G556 - G565.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. L. Kielar, R. John, M. Bennett, J. A. Richardson, J. M. Shelton, L. Chen, D. R. Jeyarajah, X. J. Zhou, H. Zhou, B. Chiquett, et al.
Maladaptive Role of IL-6 in Ischemic Acute Renal Failure
J. Am. Soc. Nephrol., November 1, 2005; 16(11): 3315 - 3325.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online
Copyright © 2003 by the American Physiological Society.