HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (28) Citing Articles via Google Scholar Google Scholar Articles by Rogers, A. B. Articles by Fox, J. G. Search for Related Content PubMed PubMed Citation Articles by Rogers, A. B. Articles by Fox, J. G.

THEMES

Inflammation and Cancer I. Rodent models of infectious gastrointestinal and liver cancer

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139

Chronic gastrointestinal and liver infections account for a significant percentage of human cancer deaths. Rodent models help elucidate how infection can lead to malignancy. Helicobacter pylori, the leading cause of human gastric tumors, produces similar disease in Mongolian gerbils. H. pylori, H. felis, and H. hepaticus induce stomach, lower bowel, or liver tumors in susceptible wild-type and genetically engineered mice. Immune dysregulated mice recapitulate features of inflammatory bowel disease including colon carcinoma. Hepatitis B and C virus transgenic mice provide insights into viral hepatitis and hepatocellular carcinoma. Rodent models enhance our understanding of infectious cancer pathogenesis and suggest novel targets for intervention.

digestive system neoplasms; Helicobacter; viral hepatitis

This article has been cited by other articles:

				R. M. Peek Jr Review: Prevention of gastric cancer: When is treatment of Helicobacter pylori warranted? Therapeutic Advances in Gastroenterology, July 1, 2008; 1(1): 19 - 31. [Abstract] [PDF]

				A. Garcia, M. M. Ihrig, R. C. Fry, Y. Feng, S. Xu, S. R. Boutin, A. B. Rogers, S. Muthupalani, L. D. Samson, and J. G. Fox Genetic Susceptibility to Chronic Hepatitis Is Inherited Codominantly in Helicobacter hepaticus-Infected AB6F1 and B6AF1 Hybrid Male Mice, and Progression to Hepatocellular Carcinoma Is Linked to Hepatic Expression of Lipogenic Genes and Immune Function-Associated Networks Infect. Immun., May 1, 2008; 76(5): 1866 - 1876. [Abstract] [Full Text] [PDF]

				A. B. Rogers, E. J. Theve, Y. Feng, R. C. Fry, K. Taghizadeh, K. M. Clapp, C. Boussahmain, K. S. Cormier, and J. G. Fox Hepatocellular Carcinoma Associated with Liver-Gender Disruption in Male Mice Cancer Res., December 15, 2007; 67(24): 11536 - 11546. [Abstract] [Full Text] [PDF]

				J. G. Fox, A. B. Rogers, M. T. Whary, Z. Ge, M. Ohtani, E. K. Jones, and T. C. Wang Accelerated Progression of Gastritis to Dysplasia in the Pyloric Antrum of TFF2 / C57BL6 x Sv129 Helicobacter pylori-Infected Mice Am. J. Pathol., November 1, 2007; 171(5): 1520 - 1528. [Abstract] [Full Text] [PDF]

				K. L. Margolis, R. J. Rodabough, C. A. Thomson, A. M. Lopez, A. McTiernan, and for the Women's Health Initiative Research Group Prospective Study of Leukocyte Count as a Predictor of Incident Breast, Colorectal, Endometrial, and Lung Cancer and Mortality in Postmenopausal Women Arch Intern Med, September 24, 2007; 167(17): 1837 - 1844. [Abstract] [Full Text] [PDF]

				J G Fox Helicobacter bilis: bacterial provocateur orchestrates host immune responses to commensal flora in a model of inflammatory bowel disease Gut, July 1, 2007; 56(7): 898 - 900. [Full Text] [PDF]

				M. T. Whary, S. J. Danon, Y. Feng, Z. Ge, N. Sundina, V. Ng, N. S. Taylor, A. B. Rogers, and J. G. Fox Rapid Onset of Ulcerative Typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) Mice Infected with Helicobacter trogontum Is Associated with Decreased Colonization by Altered Schaedler's Flora Infect. Immun., December 1, 2006; 74(12): 6615 - 6623. [Abstract] [Full Text] [PDF]

				L. Maggio-Price, P. Treuting, W. Zeng, M. Tsang, H. Bielefeldt-Ohmann, and B. M. Iritani Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice Cancer Res., January 15, 2006; 66(2): 828 - 838. [Abstract] [Full Text] [PDF]

				A. B. Rogers, N. S. Taylor, M. T. Whary, E. D. Stefanich, T. C. Wang, and J. G. Fox Helicobacter pylori but not High Salt Induces Gastric Intraepithelial Neoplasia in B6129 Mice Cancer Res., December 1, 2005; 65(23): 10709 - 10715. [Abstract] [Full Text] [PDF]

				P. R. Nambiar, S. Kirchain, and J. G. Fox Gastritis-associated Adenocarcinoma and Intestinal Metaplasia in a Syrian Hamster Naturally Infected with Helicobacter Species Vet. Pathol., May 1, 2005; 42(3): 386 - 390. [Abstract] [Full Text] [PDF]

				A. B. Rogers, S. R. Boutin, M. T. Whary, N. Sundina, Zhongming Ge, K. Cormier, and J. G. Fox Progression of Chronic Hepatitis and Preneoplasia in Helicobacter hepaticus-Infected A/JCr Mice Toxicol Pathol, October 1, 2004; 32(6): 668 - 677. [Abstract] [PDF]

				S. R. Boutin, A. B. Rogers, Zeli Shen, R. C. Fry, J. A. Love, P. R. Nambiar, S. Suerbaum, and J. G. Fox Hepatic Temporal Gene Expression Profiling in Helicobacter hepaticus-Infected A/JCr Mice Toxicol Pathol, October 1, 2004; 32(6): 678 - 693. [Abstract] [PDF]