HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 286/4/G683    most recent 00358.2003v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (13) Citing Articles via Google Scholar Google Scholar Articles by Schwetz, I. Articles by Mayer, E. A. Search for Related Content PubMed PubMed Citation Articles by Schwetz, I. Articles by Mayer, E. A.

NEUROREGULATION AND MOTILITY

Delayed stress-induced colonic hypersensitivity in male Wistar rats: role of neurokinin-1 and corticotropin-releasing factor-1 receptors

¹Center for Neurovisceral Sciences and Women's Health, Departments of Medicine, ²Physiology, ³Psychiatry and Biobehavioral Sciences, and ⁴Brain Research Institute, David Geffen School of Medicine at University of California, Los Angeles 90024; and ⁵Veterans Affairs Greater Los Angeles Healthcare System-West Los Angeles Healthcare Center, Los Angeles, California 90073

Submitted 19 August 2003 ; accepted in final form 6 November 2003

The mechanism(s) underlying stress-induced colonic hypersensitivity (SICH) are incompletely understood. Our aims were to assess the acute and delayed (24 h) effect of water avoidance (WA) stress on visceral nociception in awake male Wistar rats and to evaluate the role of two stress-related modulation systems: the substance P/neurokinin-1 receptor (SP/NK₁R) and the corticotropin-releasing factor (CRF)/CRF₁ receptor (CRF/CRF₁R) systems, as well as the possible involvement of the sympathetic nervous system. Visceral pain responses were measured as the visceromotor response to colorectal distension (CRD) at baseline, immediately after WA and again 24 h later. The NK₁R antagonists RP-67580 and SR-140333 and the CRF₁R antagonist CP-154526 were injected 15 min before WA or 1 h before the CRD on day 2. Chemical sympathectomy was performed by repeated injection of 6-hydroxydopamine. WA stress resulted in a significant increase in the visceromotor response on day 2, but no change immediately after WA. Injection of CP-154526 abolished delayed SICH when applied either before WA stress or before the CRD on day 2. Both NK₁R antagonists only decreased SICH when injected before the CRD on day 2. Chemical sympathectomy did not affect delayed SICH. Our results indicate that in male Wistar rats, both NK₁R and CRF₁R activation, but not sympathetic nervous system activation, play a role in the development of SICH.

visceral pain; stress

This article has been cited by other articles:

				A. A. Teitelbaum, M. G. Gareau, J. Jury, P. C. Yang, and M. H. Perdue Chronic peripheral administration of corticotropin-releasing factor causes colonic barrier dysfunction similar to psychological stress Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G452 - G459. [Abstract] [Full Text] [PDF]

				M. Larauche, S. Bradesi, M. Million, P. McLean, Y. Tache, E. A. Mayer, and J. A. McRoberts Corticotropin-releasing factor type 1 receptors mediate the visceral hyperalgesia induced by repeated psychological stress in rats Am J Physiol Gastrointest Liver Physiol, April 1, 2008; 294(4): G1033 - G1040. [Abstract] [Full Text] [PDF]

				E A Mayer, S Bradesi, L Chang, B M R Spiegel, J A Bueller, and B D Naliboff Functional GI disorders: from animal models to drug development Gut, March 1, 2008; 57(3): 384 - 404. [Abstract] [Full Text] [PDF]

				M Million, L Wang, Y Wang, D W Adelson, P-Q Yuan, C Maillot, S V Coutinho, J A Mcroberts, A Bayati, H Mattsson, et al. CRF2 receptor activation prevents colorectal distension induced visceral pain and spinal ERK1/2 phosphorylation in rats Gut, February 1, 2006; 55(2): 172 - 181. [Abstract] [Full Text] [PDF]

				I. Schwetz, J. A. McRoberts, S. V. Coutinho, S. Bradesi, G. Gale, M. Fanselow, M. Million, G. Ohning, Y. Tache, P. M. Plotsky, et al. Corticotropin-releasing factor receptor 1 mediates acute and delayed stress-induced visceral hyperalgesia in maternally separated Long-Evans rats Am J Physiol Gastrointest Liver Physiol, October 1, 2005; 289(4): G704 - G712. [Abstract] [Full Text] [PDF]

				S. Bradesi, I. Schwetz, H. S. Ennes, C. M. R. Lamy, G. Ohning, M. Fanselow, C. Pothoulakis, J. A. McRoberts, and E. A. Mayer Repeated exposure to water avoidance stress in rats: a new model for sustained visceral hyperalgesia Am J Physiol Gastrointest Liver Physiol, July 1, 2005; 289(1): G42 - G53. [Abstract] [Full Text] [PDF]