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This Article Full Text Full Text (PDF) All Versions of this Article: 289/6/G1015    most recent 00488.2004v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (6) Citing Articles via Google Scholar Google Scholar Articles by Báez-Ruiz, A. Articles by Díaz-Muñoz, M. Search for Related Content PubMed PubMed Citation Articles by Báez-Ruiz, A. Articles by Díaz-Muñoz, M.

LIVER AND BILIARY TRACT

Metabolic adaptations of liver mitochondria during restricted feeding schedules

¹Instituto de Neurobiología, Universidad Nacional Autónoma de México-Juriquilla, Querétaro; and ²Facultad de Medicina and ³Instituto de Fisiología Celular, Universidad Nacional Autónoma de México, México

Submitted 27 October 2004 ; accepted in final form 13 June 2005

Food anticipatory activity (FAA) is an output of the food-entrained oscillator (FEO), a conspicuous biological clock that expresses when experimental animals are under a restricted food schedule (RFS). We have shown that the liver is entrained by RFS and exhibits an anticipatory response before meal time in its oxidative and energetic state. The present study was designed to determine the mitochondrial oxidative and phosphorylating capacity in the liver of rats under RFS to further support the biochemical anticipatory role that this organ plays during the food entrainment (9). Metabolic and functional parameters of liver mitochondria were characterized before (0800 h), during (1100 h), and after (1400 h) FAA. The main results were as follows. First, there was an enhancement during FAA (1100 h) in 1) oxidative capacity (site I of the electron transport chain), 2) phosphorylating ability (estimated by ATP synthesis), and 3) activities of NADH shuttles. Second, after rats were fed (1400 h), the phosphorylating capacity remained high, but this was not the case for the respiratory control ratio for site I. Finally, in the three experimental conditions before, during, and after FAA, an increment was detected in the H⁺ electrochemical potential, due to an elevation in mitochondrial membrane potential, and in mitochondrial yield. Most of the changes in mitochondrial properties related to RFS were also present when results were compared with those from the 24-h fasted group. In conclusion, the results support the notion that a distinctive rheostatic state is installed in the metabolic activity of the liver when FEO is being expressed.

metabolism; food-entrainable oscillator; oxidation; swelling; H⁺ electrochemical potential; change in pH; mitochondrial membrane potential

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