HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) All Versions of this Article: 290/5/G1051    most recent 00429.2005v1 Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Web of Science (11) Citing Articles via Google Scholar Google Scholar Articles by Kanai, T. Articles by Watanabe, M. Search for Related Content PubMed PubMed Citation Articles by Kanai, T. Articles by Watanabe, M.

MUCOSAL BIOLOGY

Naturally arising CD4⁺CD25⁺ regulatory T cells suppress the expansion of colitogenic CD4⁺CD44^highCD62L^– effector memory T cells

Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan

Submitted 12 September 2005 ; accepted in final form 15 December 2005

Naturally arising CD4⁺CD25⁺ regulatory T (T_R) cells have been shown to prevent and cure murine T cell-mediated colitis. However, their exact mechanism of controlling colitogenic memory CD4⁺ T cells in in vivo systems excluding the initial process of naive T cell activation and differentiation has not been examined to date. Using the colitogenic effector memory (T_EM) CD4⁺ cell-mediated colitis model induced by adoptive transfer of colitogenic CD4⁺CD44^highCD62L^– lamina propria (LP) T cells obtained from colitic CD4⁺CD45RB^high T cell-transferred mice, we have shown in the present study that CD4⁺CD25⁺ T_R cells are able not only to suppress the development of colitis, Th1 cytokine production, and the expansion of colitogenic LP CD4⁺ T_EM cells but also to expand these cells by themselves extensively in vivo. An in vitro coculture assay revealed that CD4⁺CD25⁺ T_R cells proliferated in the presence of IL-2-producing colitogenic LP CD4⁺ T_EM cells at the early time point (48 h after culture), followed by the acquisition of suppressive activity at the late time point (96 h after culture). Collectively, these data suggest the distinct timing of the IL-2-dependent expansion of CD4⁺CD25⁺ T_R cells and the their suppressive activity on colitogenic LP CD4⁺ T_EM cells.

murine colitis model; interleukin-2

This article has been cited by other articles:

				C. Q. Nie, N. J. Bernard, L. Schofield, and D. S. Hansen CD4+ CD25+ Regulatory T Cells Suppress CD4+ T-Cell Function and Inhibit the Development of Plasmodium berghei-Specific TH1 Responses Involved in Cerebral Malaria Pathogenesis Infect. Immun., May 1, 2007; 75(5): 2275 - 2282. [Abstract] [Full Text] [PDF]