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Am J Physiol Gastrointest Liver Physiol 290: G847-G851, 2006; doi:10.1152/ajpgi.00522.2005
0193-1857/06 $8.00
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THEMES

Mechanisms of Liver Injury. III. Oxidative stress in the pathogenesis of hepatitis C virus

Jinah Choi1 and J.-H. James Ou2

1School of Natural Sciences, University of California, Merced, California; and 2Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California

Hepatitis C virus (HCV) is a major cause of viral hepatitis that can progress to hepatic fibrosis, steatosis, hepatocellular carcinoma, and liver failure. HCV infection is characterized by a systemic oxidative stress that is most likely caused by a combination of chronic inflammation, iron overload, liver damage, and proteins encoded by HCV. The increased generation of reactive oxygen and nitrogen species, together with the decreased antioxidant defense, promotes the development and progression of hepatic and extrahepatic complications of HCV infection. This review discusses the possible mechanisms of HCV-induced oxidative stress and its role in HCV pathogenesis.

reactive oxygen species; reactive nitrogen species; antioxidant; hepatic fibrosis; hepatocellular carcinoma


Address for reprint requests and other correspondence: J.-H. Ou, Dept. of Molecular Microbiology and Immunology, Univ. of Southern California, Keck School of Medicine, 2011 Zonal Ave., HMR-401, Los Angeles, CA 90033 (e-mail: jamesou{at}hsc.usc.edu)




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