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THEMES

TLRS in the Gut. II. Flagellin-induced inflammation and antiapoptosis

Department of Pathology, Emory University School of Medicine, Atlanta, Georgia

Submitted 20 June 2006 ; accepted in final form 7 July 2006

Flagellin is bacterial protein that serves as a danger signal across a wide variety of eukaryotes and is a potent inducer of inflammatory effector responses in the mammalian gut. Recent findings utilizing purified flagellin and flagellate/aflagellate bacteria in in vitro and in vivo systems have revealed the important roles played by flagellin in the initial encounter between mucosa and flagellate bacteria, specifically in the modulation of apoptotic responses.

Toll-like receptor 5; inflammation; apoptosis; bacterial pathogenesis; colitis; epithelia